Nuclear receptor coactivators

Nuclear receptor coactivators
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DOI:
10.1016/s0955-0674(97)80066-x
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发表时间:
1997-04-01
影响因子:
7.5
通讯作者:
Rosenfeld, MG
Rosenfeld, MG
中科院分区:
生物学2区
文献类型:
--
作者:
Glass, CK;Rose, DW;Rosenfeld, MG

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Retinoic acid, steroid and thyroid hormones regulate complex programs of gene expression by binding to intracellular receptors that are members of the nuclear receptor superfamily of ligand-dependent transcription factors. Recent studies have led to the identification and cloning of genes encoding coactivator molecules that appear to play important roles in mediating ligand-dependent transcription by members of this family, The identification of these coactivator molecules suggests a paint of entry into the general transcriptional machinery that is common to several other classes of regulated transcription factors.