Protein-Mimetic Self-Assembly with Synthetic Macromolecules
Protein-Mimetic Self-Assembly with Synthetic Macromolecules
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DOI：
10.1021/acs.macromol.0c02826
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发表时间：
2021-03-09
期刊：
影响因子：
5.5
通讯作者：
Knight, Abigail S.
中科院分区：
文献类型：
--
作者：
Barbee, Meredith H.;Wright, Zoe M.;Knight, Abigail S.
模拟蛋白质的两亲性作为一种平台具有重要的前景，可以获得天然生物材料的复杂功能，并结合合成材料的可调性和环境弹性。聚合物化学和化学生物学领域同时探讨了仿生两亲性材料的发展，材料范围从无规两亲共聚物到肽-脂结合物。在这个视角下，我们结合了来自不同化学领域的策略，以控制模拟蛋白质的合成大分子的组装形态和动力学。综述了多肽两亲性和单链聚合物纳米粒子的重要进展，为比较多种分子间相互作用的实现和微调组装结构的计算策略方面的最新进展提供了基础。我们的目标是搭建这些领域的桥梁，将来自多个学科的见解结合起来，以启发开发蛋白质模拟材料的新方法，因为这些组件具有深远的应用，包括在开发新的传感器、催化剂和疗法方面。
Protein-mimetic amphiphiles have significant promise as a platform to access the complex functions of natural biological materials and incorporate the tunability and environmental resilience of synthetic materials. The fields of polymer chemistry and chemical biology have concurrently approached the development of biomimetic amphiphiles with materials ranging from random amphiphilic copolymers to peptide-lipid conjugates. In this Perspective, we incorporate strategies from diverse chemical arenas for controlling assembled morphologies and dynamics of protein-mimetic synthetic macromolecules. An overview of significant advances in peptide amphiphiles and single-chain polymer nanoparticles provides the foundation for comparing recent advances in the implementation of multiple intermolecular interactions and computational strategies to fine-tune the assembled structures. We aim to bridge these fields, combining insights from multiple disciplines to inspire new approaches for the development of protein-mimetic materials, as these assemblies have far-reaching applications including in the development of new sensors, catalysts, and therapeutics.