Social isolation alters neuroinflammatory response to stroke
Social isolation alters neuroinflammatory response to stroke
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DOI：
10.1073/pnas.0810737106
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发表时间：
2009-04-07
影响因子：
11.1
通讯作者：
DeVries, A. Courtney
中科院分区：
文献类型：
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作者：
Karelina, Kate;Norman, Greg J.;DeVries, A. Courtney
社会隔离具有显著的长期生理和心理后果;然而，社会隔离影响疾病结果的机制在很大程度上是未知的。本研究旨在探讨社交隔离对局灶性脑缺血后神经元损伤、神经炎症和功能结局的影响。在通过短暂性管腔内大脑中动脉闭塞（MCAO）或假手术诱导中风之前，将雄性小鼠与卵巢切除的雌性小鼠社会隔离（单独圈养）或成对圈养。在这些实验中，缺血周围的社会隔离降低中风后存活率，并加剧梗死面积和水肿的发展。对缺血性损伤的社会影响伴随着改变的神经炎症反应;具体而言，相对于社会圈养的小鼠，在隔离的小鼠中，中枢白细胞介素-6（IL-6）信号转导下调，而外周IL-6上调。此外，脑室内注射IL-6中和抗体（10 ng）消除了缺血性结局测量中的社会住房差异。总之，这些数据表明，中央IL-6是一个重要的介导的社会影响中风的结果。
Social isolation has dramatic long-term physiological and psychological consequences; however, the mechanisms by which social isolation influences disease outcome are largely unknown. The purpose of the present study was to investigate the effects of social isolation on neuronal damage, neuroinflammation, and functional outcome after focal cerebral ischemia. Male mice were socially isolated (housed individually) or pair housed with an ovariectomized female before induction of stroke, via transient intraluminal middle cerebral artery occlusion (MCAO), or SHAM surgery. In these experiments, peri-ischemic social isolation decreases poststroke survival rate and exacerbates infarct size and edema development. The social influence on ischemic damage is accompanied by an altered neuroinflammatory response; specifically, central interleukin-6 (IL-6) signaling is down-regulated, whereas peripheral IL-6 is up-regulated, in isolated relative to socially housed mice. In addition, intracerebroventricular injection of an IL-6 neutralizing antibody (10 ng) eliminates social housing differences in measures of ischemic outcome. Taken together, these data suggest that central IL-6 is an important mediator of social influences on stroke outcome.