Radioimmunoassay of cardiac myosin light chain II in the serum following experimental myocardial infarction.
Radioimmunoassay of cardiac myosin light chain II in the serum following experimental myocardial infarction.
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实验性心肌梗死后血清中心肌肌球蛋白轻链 II 的放射免疫测定。
DOI：
10.1016/0006-291x(79)91767-4
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
Y. Yazaki
中科院分区：
文献类型：
--
作者：
R. Nagai;S. Ueda;Y. Yazaki
建立了心肌肌球蛋白轻链Ⅱ（LC Ⅱ）放射免疫分析法，并观察了实验性心肌梗塞犬血清LC Ⅱ水平的变化。在我们的测定中，0.2-5 ng的LC II是有效可测量的。冠状动脉闭塞后血清LC Ⅱ水平的时程曲线有两个特点，这在血清酶研究中没有观察到：1。(1)LC Ⅱ水平升高迅速，并长期维持在较高水平。(2)部分病例血清LC Ⅱ水平呈双相变化。
A sensitive radioimmunoassay of cardiac myosin light chain II (LC II) was developed, and changes of serum LC II levels were studied in experimental myocardial infarction in dogs. In our assay, 0.2–5 ng of LC II were effectively measurable. The time-course curves of serum LC II level after coronary occlusion had two characteristics which had not been observed in serum enzyme studies;1.(1) LC II level rose rapidly and stayed up during a long period,2.(2) changes of serum LC II levels were biphasic in some cases.