Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1.
Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1.
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发表时间：
1990-07
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通讯作者：
B. Kacinski;D. Carter;K. Mittal;L. Yee;K. Scata;L. Donofrio;S. Chambers;Kuan I. Wang;T. Yang-Feng
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作者：
B. Kacinski;D. Carter;K. Mittal;L. Yee;K. Scata;L. Donofrio;S. Chambers;Kuan I. Wang;T. Yang-Feng
在卵巢和子宫内膜肿瘤癌基因表达的早期研究中，作者报道了高水平的fms互补转录物与高组织学分级和晚期临床分期相关。在这篇文章中，他们通过原位杂交和免疫组织化学研究证实了14例卵巢浸润性腺癌中14例的恶性上皮细胞表达fms互补转录本。通过北方印迹和逆转录，然后聚合酶链反应扩增，作者也能够证明fms转录表达在几个卵巢和子宫内膜癌衍生的细胞系。由于约有一半（6/14）的浸润性腺癌标本共表达fms和集落刺激因子1，作者提出卵巢腺癌表达这种淋巴造血细胞因子及其受体可能有助于其体内增殖和浸润特性。
In earlier studies of oncogene expression in ovarian and endometrial neoplasms, the authors reported that high tumor levels of fms-complementary transcripts correlate with high histologic grade and advanced clinical stage presentations. In this communication, they pursue these initial clinicopathologic investigations to demonstrate by in situ hybridization and immunohistochemistry that malignant epithelial cells of 14 of 14 invasive adenocarcinomas of the ovary express fms-complementary transcripts. By Northern blotting and by reverse transcription, followed by polymerase chain reaction amplification, the authors also were able to demonstrate fms transcript expression in several ovarian and endometrial carcinoma-derived cell lines. Because about half (6/14) of the invasive adenocarcinoma specimens were shown to coexpress fms and colony-stimulating factor 1, the authors propose that the expression of this lymphohematopoietic cytokine and its receptor by ovarian adenocarcinomas could contribute to their proliferative and invasive characteristics in vivo.