Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats
Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats
复制标题
成纤维细胞生长因子5-short (FGF5s)抑制绒山羊初级和次级毛囊真皮乳头细胞中FGF5的活性
DOI：
10.1016/j.gene.2015.09.034
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发表时间：
2016-01-10
期刊：
影响因子：
3.5
通讯作者：
Chen, Yulin
中科院分区：
文献类型：
--
作者：
He, Xiaolin;Chao, Yuan;Chen, Yulin
目的探讨绒山羊初级毛囊和次级毛囊毛乳头细胞中成纤维细胞生长因子5（FGF 5）和短型成纤维细胞生长因子5（FGF 5s）的关系。从绒山羊的初级毛囊（PHF）和次级毛囊（SHF）中分离毛乳头细胞，发现成纤维细胞生长因子受体1（FGFR 1）在这两种毛乳头细胞中均有表达。此外，腺病毒介导的FGF 5过表达可以上调胰岛素样生长因子-1（IGF-1），多功能蛋白聚糖和noggin的mRNA表达，而下调毛乳头细胞生长期抑素骨形态发生蛋白4（BMP 4）的表达。然而，这些改变被FGF 5s过表达部分逆转。综上所述，我们的研究结果表明，FGF 5s作为FGF 5的抑制剂，在调节绒山羊毛乳头细胞的生长期-退化期的转变。(C)2015爱思唯尔B. V.保留所有权利。
To determine the relationship between fibroblast growth factor 5 (FGF5) and FGF5-short (FGF5s) in dermal papilla cells of cashmere goat primary and secondary hair follicles. We isolated dermal papilla cells from primary hair follicle (PHF) and secondary hair follicle (SHF) of cashmere goat, and found that the FGF5 receptor, fibroblast growth factor receptor 1 (FGFR1), was expressed in these two types of dermal papilla cells. Moreover, adenovirus-mediated overexpression of FGF5 could upregulate the mRNA expression of insulin-like growth factor-1 (IGF-1), versican and noggin that were important for follicle growth maintenance, whereas downregulate the expression of anagen chalone bone morphogenetic protein 4 (BMP4) in dermal papilla cells. However, these alterations were partly reversed by FGF5s overexpression. In conclusion, our results demonstrated that FGF5s acted as an inhibitor of FGF5 in the regulation of anagen-catagen transition of cashmere goat dermal papilla cells. (C) 2015 Elsevier B.V. All rights reserved.