Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats
Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats
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DOI：
10.1016/j.ejphar.2015.05.027
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发表时间：
2015-09-05
影响因子：
5
通讯作者：
Amancio-dos-Santos, Angela
中科院分区：
文献类型：
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作者：
Costa Monteiro, Heloisa Mirelle;Barreto-Silva, Nathalia Lima;Amancio-dos-Santos, Angela
抗抑郁药氟西汀和体育锻炼通过增加大脑5-羟色胺的可用性对肾上腺素能系统产生类似的作用，并且两者都对皮层兴奋性表现出拮抗作用。在这里，我们提供了第一次评估的相互作用，两者一起对皮质扩散性抑制（CSD）在年轻的成年大鼠。Wistar大鼠（40-60天）接受氟西汀（10 mg/kg/d，口胃）或等量的水。每种情况下，一半的动物被分配到跑步机上进行体育锻炼，另一半形成久坐（非跑步机）的对照组。身体参数（李指数和胸，腹围）和CSD的传播速度进行了调查。氟西汀+运动组动物的体重增加（78.68 +/- 3.19 g）低于仅氟西汀组（93.34 +/- 477 g）或仅运动组（9704 +/- 348 g），但它们之间的身体参数没有差异。与久坐不动的水对照组相比，仅氟西汀组和仅运动组的CSD传播速度降低（3.24 +/- 0.39 mm/min）。对于氟西汀+运动组，CSD速度值（2.92 +/- 0.22 mm/min）显著低于仅氟西汀组（3.03 +/- 0.35 mm/min）;然而，它们与仅运动组的值（2.96 +/- 0.23 mm/min）相似。这些发现证实了氟西汀和运动的相似作用，并表明体育锻炼在降低大脑兴奋性方面的作用更大。(C)2015 Elsevier B. V.版权所有。
The antidepressant fluoxetine and physical exercise exert similar effects on the serotoninergic system by increasing brain serotonin availability, and both show antagonistic action on cortical excitability. Here we provide the first assessment of the interaction of the two together on cortical spreading depression (CSD) in young adult rats. Wistar rats (40-60 days of life) received fluoxetine (10 mg/kg/d, orogastrically) or an equivalent volume of water. Half of the animals from each condition were assigned to perform physical exercise in a treadmill, and the other half formed the sedentary (non-treadmill) control groups. Body parameters (Lee index and thoracic and abdominal circumferences) and the velocity of CSD propagation were investigated. Fluoxetine + exercise animals had less weight gain (78.68 +/- 3.19 g) than either the fluoxetine-only (93.34 +/- 477 g) or exercise-only group (9704 +/- 348 g), but body parameters did not differ among them. The velocity of CSD propagation was reduced in the fluoxetine-only and exercise-only groups compared to sedentary water controls (3.24 +/- 0.39 mm/min). For the fluoxetine + exercise group, CSD velocity values were significantly lower (2.92 +/- 0.22 mm/min) than for fluoxetine only (3.03 +/- 0.35 mm/min); however, they were similar to values for the exercise-only group (2.96 +/- 0.23 mm/min). These findings confirm the similar effects of fluoxetine and exercise and suggest a greater effect of physical exercise in reducing brain excitability. (C) 2015 Elsevier B.V. All rights reserved.