Six-gene signature for predicting survival in patients with head and neck squamous cell carcinoma
Six-gene signature for predicting survival in patients with head and neck squamous cell carcinoma
复制标题
用于预测头颈鳞状细胞癌患者生存的六基因特征
DOI：
10.18632/aging.102655
复制
发表时间：
2020-01-15
期刊：
影响因子：
5.2
通讯作者：
Cai, Gengming
中科院分区：
文献类型：
--
作者：
Wang, Juncheng;Chen, Xun;Cai, Gengming
The prognosis of head and neck squamous cell carcinoma (HNSCC) patients remains poor. High-throughput sequencing data have laid a solid foundation for identifying genes related to cancer prognosis, but a gene marker is needed to predict clinical outcomes in HNSCC. In our study, we downloaded RNA Seq, single nucleotide polymorphism, copy number variation, and clinical follow-up data from TCGA. The samples were randomly divided into training and test. In the training set, we screened genes and used random forests for feature selection. Gene-related prognostic models were established and validated in a test set and GEO verification set. Six genes (PEX11A, NLRP2, SERPINE1, UPK, CTTN, D2HGDH) were ultimately obtained through random forest feature selection. Cox regression analysis confirmed the 6-gene signature is an independent prognostic factor in HNSCC patients. This signature effectively stratified samples in the training, test, and external verification sets (P < 0.01). The 5-year survival AUC in the training and verification sets was greater than 0.74. Thus, we have constructed a 6-gene signature as a new prognostic marker for predicting survival of HNSCC patients.
