Antibacterial and hemolytic activities of quaternary pyridinium functionalized polynorbornenes
Antibacterial and hemolytic activities of quaternary pyridinium functionalized polynorbornenes
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DOI：
10.1002/macp.200700418
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发表时间：
2008-03-05
影响因子：
2.5
通讯作者：
Tew, Gregory N.
中科院分区：
文献类型：
--
作者：
Eren, Tarik;Som, Abhigyan;Tew, Gregory N.
本研究合成了具有不同季烷基吡啶侧链的两亲性聚硅氧烷。通过细菌生长抑制测定和对人红细胞（RBC）的溶血活性（HC（50））来确定具有各种烷基取代基的这些聚合物的生物学效率，以提供这些聚合物对细菌超过哺乳动物细胞的选择性。制备了一系列具有不同烷基取代基（乙基、丁基、己基、辛基、癸基和苯乙基）和两种不同分子量（3和10 kDa）的聚合物。烷基链长度的影响将生物活性分为两种不同的情况：具有含四个或更少碳的烷基取代基的那些具有200 μ g的最小抑制浓度（MIC）。mL（-1）和HC（50）大于1650 μ g。mL（-1），而具有6个或更多碳的那些具有较低的MIC
In this study, amphiphilic polyoxanorbornene with different quaternary alkyl pyridinium side chains were synthesized. The biological efficiencies of these polymers, with various alkyl substituents, were determined by bacterial growth inhibition assays and hemolytic activity (HC(50)) against human red blood cells (RBCs) to provide selectivity of these polymers for bacterial over mammalian cells. A series of polymers with different alkyl substituents (ethyl, butyl, hexyl, octyl, decyl and phenylethyl) and two different molecular weights (3 and 10 kDa) were prepared. The impact of alkyl chain length divided the biological activity into two different cases: those with an alkyl substituent containing four or fewer carbons had a minimum inhibitory concentration (MIC) of 200 mu g . mL(-1) and a HC(50) greater than 1650 mu g . mL(-1), while those with six or more carbons had lower MICs