EPIZOOTIOLOGY OF HANTAVIRUS INFECTIONS IN BALTIMORE - ISOLATION OF A VIRUS FROM NORWAY RATS, AND CHARACTERISTICS OF INFECTED-RAT POPULATIONS
EPIZOOTIOLOGY OF HANTAVIRUS INFECTIONS IN BALTIMORE - ISOLATION OF A VIRUS FROM NORWAY RATS, AND CHARACTERISTICS OF INFECTED-RAT POPULATIONS
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DOI：
10.1093/oxfordjournals.aje.a114662
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发表时间：
1987-07-01
影响因子：
5
通讯作者：
SHAH, KV
中科院分区：
文献类型：
--
作者：
CHILDS, JE;KORCH, GW;SHAH, KV
从马里兰州的巴尔的摩的14个地点捕获的老鼠被证明具有汉坦病毒抗体。居民区抗体流行率高于公园。从1980年至1985年，在五个地点连续六年获得受感染的大鼠，表明这种感染在美国城市大鼠中的地方病性质。抗体和几何平均滴度的患病率随着大鼠体重和性成熟度的增加而增加，表明大鼠感染是通过年龄相关机制获得的。从大鼠中分离到3株汉坦病毒。血清学试验和单克隆抗体反应模式显示，这些分离株之一与先前从费城获得的大鼠病毒相似（如果不相同）。在许多城市环境中存在的大鼠和汉坦病毒感染的高患病率在这个物种表明，人类暴露于这种病毒正在发生在美国，虽然人类疾病，从这种暴露尚未得到承认。
Rats trapped from 14 locations in Baltimore, Maryland, were shown to have antibody to Hantavirus. Antibody prevalence rates were higher in residential locations than in parks. Infected rats were rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection in urban rats in the United States. Prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired through age-related mechanisms. Three isolates of Hantavirus were obtained from rats. One of these isolates was shown by serologic tests and monoclonal antibody reactivity patterns to be similar, if not identical, to rat virus previously obtained from Philadelphia. The presence of rats in many urban settings and the high prevalence of Hantavirus infection in this species suggest that human exposure to this virus is occurring in the United States, although human disease from this exposure has not been recognized.