Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12).
Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12).
复制标题
心房钠尿因子抑制肾上腺素能克隆细胞系 (PC12) 中去甲肾上腺素的释放。
DOI：
10.1016/0014-2999(88)90765-0
复制
发表时间：
1988
影响因子：
5
通讯作者：
Trachte,G
中科院分区：
文献类型：
--
作者：
Drewett,J;Marchand,G;Ziegler,R;Trachte,G
Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.
