The emerging role of neutrophils in thrombosis-the journey of TF through NETs.
The emerging role of neutrophils in thrombosis-the journey of TF through NETs.
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DOI：
10.3389/fimmu.2012.00385
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发表时间：
2012
影响因子：
7.3
通讯作者：
Ritis K
中科院分区：
文献类型：
--
作者：
Kambas K;Mitroulis I;Ritis K
直到最近，中性粒细胞产生TF及其在血栓形成中的作用仍是一个科学争论的问题。实验数据表明，从头TF生产的中性粒细胞炎症刺激下，而其他人提出，这些细胞获得微粒衍生的TF。最近的实验证据表明，中性粒细胞在血栓事件中的关键作用。在几种人类和动物模型中，神经元衍生的TF与该过程有关。此外，中性粒细胞胞外陷阱（NET）释放已成为疾病模型（包括败血症、深静脉血栓形成和恶性肿瘤）中嗜中性粒细胞驱动的血栓形成的主要贡献者。这表明，NETs提供的支架纤维蛋白沉积和血小板截留和随后的激活。最近报道的自噬依赖性细胞外传递的TF在NET进一步支持中性粒细胞参与血栓形成。在此，我们试图审查新的数据，中性粒细胞在血栓形成中的作用，强调TF和NET的影响。
The production of TF by neutrophils and their contribution in thrombosis was until recently a matter of scientific debate. Experimental data suggested the de novo TF production by neutrophils under inflammatory stimuli, while others proposed that these cells acquired microparticle-derived TF. Recent experimental evidence revealed the critical role of neutrophils in thrombotic events. Neutrophil derived TF has been implicated in this process in several human and animal models. Additionally, neutrophil extracellular trap (NET) release has emerged as a major contributor in neutrophil-driven thrombogenicity in disease models including sepsis, deep venous thrombosis, and malignancy. It is suggested that NETs provide the scaffold for fibrin deposition and platelet entrapment and subsequent activation. The recently reported autophagy-dependent extracellular delivery of TF in NETs further supports the involvement of neutrophils in thrombosis. Herein, we seek to review novel data regarding the role of neutrophils in thrombosis, emphasizing the implication of TF and NETs.
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影响因子：
4.4
作者：
Kambas, Konstantinos;Markiewski, Maciej M.;Ritis, Konstantinos D.
通讯作者：
Ritis, Konstantinos D.
影响因子：
15.9
作者：
FOLKESSON, HG;MATTHAY, MA;BROADDUS, VC
通讯作者：
BROADDUS, VC
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Kubes, Paul
DOI：
10.1084/jem.20061301
发表时间：
2007-04-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jaillon S;Peri G;Delneste Y;Frémaux I;Doni A;Moalli F;Garlanda C;Romani L;Gascan H;Bellocchio S;Bozza S;Cassatella MA;Jeannin P;Mantovani A
通讯作者：
Mantovani A