Air pollution from traffic at the residence of children with cancer
Air pollution from traffic at the residence of children with cancer
复制标题
DOI：
10.1093/aje/153.5.433
复制
发表时间：
2001-03-01
影响因子：
5
通讯作者：
Olsen, JH
中科院分区：
文献类型：
--
作者：
Raaschou-Nielsen, O;Hertel, O;Olsen, JH
对儿童时期暴露于与交通有关的空气污染会增加患癌症风险的假设进行了调查。作者招募了1968-1991年期间在丹麦癌症登记处报告的1，989名儿童，他们被诊断为白血病，中枢神经系统肿瘤或恶性淋巴瘤，并从整个儿童人群中随机选择了5，506名对照儿童。从出生前9个月起追踪儿童的居住史，直到诊断病例和对照组的相似时期。对于确定的18，440个地址中的每一个，收集了有关交通以及街道和建筑物配置的信息。计算了相关时期苯和二氧化氮（与交通有关的空气污染指标）的平均浓度，并分别计算了怀孕期间和儿童期间的空气污染暴露。白血病、中枢神经系统肿瘤和所有选定的癌症的风险总和与在这两个时期接触苯或二氧化氮无关。在妊娠期间，苯和二氧化氮浓度加倍，淋巴瘤的风险分别增加25%（趋势p = 0.06）和51%（趋势p = 0.05）。这种关联仅限于霍奇金病。
The hypothesis that exposure to traffic-related air pollution increases the risk of developing cancer during childhood was investigated. The authors enrolled 1,989 children reported to the Danish Cancer Registry with a diagnosis of leukemia, tumor of the central nervous system, or malignant lymphoma during 1968-1991 and 5,506 control children selected at random from the entire childhood population. The residential histories of the children were traced from 9 months before birth until the time of diagnosis of the cases and a similar period for the controls. For each of the 18.440 identified addresses, information on traffic and the configuration of streets and buildings was collected. Average concentrations of benzene and nitrogen dioxide (indicators of traffic-related air pollution) were calculated for the relevant period, and exposures to air pollution during pregnancy and during childhood were calculated separately. The risks of leukemia, central nervous system tumors, and all selected cancers combined were not linked to exposure to benzene or nitrogen dioxide during either period. The risk of lymphomas increased by 25% (p for trend = 0.06) and 51% (p for trend = 0.05) for a doubling of the concentration of benzene and nitrogen dioxide, respectively, during the pregnancy. The association was restricted to Hodgkin's disease.