Central chemosensitivity of respiration: a brief overview
Central chemosensitivity of respiration: a brief overview
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DOI：
10.1016/s0034-5687(01)00297-3
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发表时间：
2001-12-01
期刊：
影响因子：
--
通讯作者：
Scheid, P
中科院分区：
文献类型：
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作者：
Ballantyne, D;Scheid, P
在这篇介绍性文章中，我们利用本特刊（Respir.Physiol.，2001）的许多贡献者详细审查的工作来提供当前识别脑干 CO2/pH 化学敏感神经元的方法的概述。我们采用的章节标题旨在反映特定问题而不是实验技术，尽管其中一些问题是由制备方法的选择以及这种选择带来的优点和局限性引起的。我们还考虑了，尽管通常被认为对化学敏感的神经元种类存在多样性，但是否存在任何共同或一致特征的迹象。同样，这是基于本卷中一起出版的材料。最后，更具推测性的是，我们认为化学敏感神经元的树突组织可能在化学感受中发挥重要作用。它不仅是一种对刺激进行采样的方法，也是一种区分 pH 值与神经元活动其他方面的影响的方法。 (C) 2001 Elsevier Science B.V. 保留所有权利。
In this introductory article we make use of the work reviewed in detail by a number of contributors to this Special Issue (Respir. Physiol., 2001) to provide an outline of current approaches to identifying brainstem CO2/pH-chemosensitive neurones. The section headings which we have adopted are intended to reflect particular issues rather than experimental techniques, though some of these issues arise out of the choice of preparation and the advantages and limitations which follow from such a choice. We have also considered whether, in spite of the diversity in the kinds of neurones usually considered to be chemosensitive, there are any indications for shared or uniform features. Again, this is based on the material published together in this volume. Finally, and more speculatively, we suggest that the dendritic organization of chemosensitive neurones may play an important role in chemoreception. not simply as a means of sampling the stimulus but also as a way of compartmentalizing the effects of pH in relation to other aspects of a neurone's activity. (C) 2001 Elsevier Science B.V. All rights reserved.