The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
The impact of the level of the intestinal short chain Fatty acids in inflammatory bowel disease patients versus healthy subjects.
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DOI：
10.2174/1874091x01004010053
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发表时间：
2010-05-13
期刊：
影响因子：
--
通讯作者：
Loong YY
中科院分区：
文献类型：
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作者：
Huda-Faujan N;Abdulamir AS;Fatimah AB;Anas OM;Shuhaimi M;Yazid AM;Loong YY
本研究的目的是确定与健康受试者相比，炎症性肠病（IBD）患者粪便中短链脂肪酸（SCFAs）的变化。通过使用高效液相色谱法（HPLC）分析SCFAs，如乳酸、甲酸、乙酸、丙酸、异丁酸和丁酸。这项研究表明，IBD粪便样本中乙酸（162.0 µmol/g湿粪便）、丁酸（86.9 µmol/g湿粪便）和丙酸（65.6 µmol/g湿粪便）的水平显著低于健康个体（分别为209.7、176.0和93.3 µmol/g湿粪便）。相反，IBD患者粪便中的乳酸和维生素C水平高于健康受试者。在丁酸水平的背景下，本研究还发现，在两种粪便样品中丁酸的摩尔比高于丙酸。这可能是由于马来西亚人口从大米中摄入了大量淀粉。结论：健康受试者和IBD患者粪便样本中SCFAs的水平显著不同，这提供了SCFAs更可能在IBD的发病机制中发挥重要作用的证据。
The aim of this study was to determine the changes of short chain fatty acids (SCFAs) in faeces of inflammatory bowel disease (IBD) patients compared to healthy subjects. SCFAs such as pyruvic, lactic, formic, acetic, propionic, isobutyric and butyric acids were analyzed by using high performance liquid chromatography (HPLC). This study showed that the level of acetic, 162.0 µmol/g wet faeces, butyric, 86.9 µmol/g wet faeces, and propionic acids, 65.6 µmol/g wet faeces, decreased remarkably in IBD faecal samples when compared with that of healthy individuals, 209.7, 176.0, and 93.3 µmol/g wet faeces respectively. On the contrary, lactic and pyruvic acids showed higher levels in faecal samples of IBD than in healthy subjects. In the context of butyric acid level, this study also found that the molar ratio of butyric acid was higher than propionic acid in both faecal samples. This might be due to the high intake of starch from rice among Malaysian population. It was concluded that the level of SCFAs differ remarkably between faecal samples in healthy subjects and that in IBD patients providing evidence that SCFAs more likely play an important role in the pathogenesis of IBD.