Liver Transplantation for Cholestatic Liver Diseases in Adults.
Liver Transplantation for Cholestatic Liver Diseases in Adults.
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DOI：
10.1016/j.cld.2015.08.011
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发表时间：
2016-02
影响因子：
5.1
通讯作者：
Goldberg DS
中科院分区：
文献类型：
--
作者：
Khungar V;Goldberg DS
肝移植 (LT) 是针对胆汁淤积性肝病患者的一种既定救生疗法，包括原发性胆汁淤积性疾病，即原发性硬化性胆管炎 (PSC) 和原发性胆汁性肝硬化 (PBC)，以及继发性胆汁淤积性肝病，包括那些因 LT 出现胆汁淤积并发症而需要再次移植的患者。患有胆汁淤积性肝病的患者可以因终末期肝病的并发症或终末期肝病发作前的疾病特异性症状而进行移植。胆汁淤积性肝病患者需要定期评估症状、实验室参数、肝胆肿瘤的发展情况以及伴随的 IBD 状况（如果存在），包括结肠癌筛查。胆汁淤积性肝病肝移植后患者的生存率通常优于其他适应症的患者。
Liver transplantation (LT) is an established lifesaving therapy for patients with cholestatic liver diseases, including primary cholestatic diseases, namely primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC), as well as secondary forms of cholestatic liver disease, including those with cholestatic complications of LT needing a re-transplant. Patients with cholestatic liver diseases can be transplanted for either complications of end stage liver disease or for disease-specific symptoms prior to the onset of end stage liver disease. Patients with cholestatic liver disease need to be regularly assessed for symptoms, lab parameters, development of hepatobiliary tumors, and the status of concomitant IBD if present, including colon cancer screening. Patient survival after liver transplantation for cholestatic liver diseases is generally better than for other indications.