Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression.
Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression.
复制标题
广泛性焦虑症和难治性抑郁症患者的线平分表现
DOI：
10.7150/ijms.7.224
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发表时间：
2010-07-02
影响因子：
3.6
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
He W;Chai H;Zhang Y;Yu S;Chen W;Wang W
背景和目的真实中心左侧的线对分误差被解释为相对右半球的激活，这可能与受试者的情绪状态有关。考虑到患有广泛性焦虑症(GAD)或难治性抑郁症(TRD)的患者经常有负面情绪，我们假设这些患者会显著向左一分线。方法对56例右利手健康志愿者、47例广泛性焦虑症患者和52例TRD门诊患者进行线平分测试。受试者还完成了Zuckerman-Kuhlman个性问卷、Zuckerman感觉寻求量表和Plutchik-van Praag抑郁量表。结果广泛性阿尔茨海默病患者在神经质-焦虑特质上得分最高，抑郁得分最高，社交特质得分较低。与健康受试者相比，广泛性焦虑症患者的线条也明显向左平分。在健康被试中，对分错误的出现频率与去抑制寻求呈负相关，在广泛性痴呆患者中与总感觉寻求和经验寻求呈负相关，而在TRD患者中，线对分错误的大小与抑郁呈负相关。结论GAD患者右半球激活较强，左侧激活较弱，或两者皆有，而不是TRD患者。
Background and Objectives The line bisection error to the left of the true center has been interpreted as a relative right hemisphere activation, which might relate to the subject's emotional state. Considering that patients with generalized anxiety disorder (GAD) or treatment-resistant depression (TRD) often have negative emotions, we hypothesized that these patients would bisect lines significantly leftward. Methods We tried the line bisection task in the right-handed healthy volunteers (n = 56), GAD (n = 47) and TRD outpatients (n = 52). Subjects also completed the Zuckerman - Kuhlman Personality Questionnaire, the Zuckerman Sensation Seeking Scales, and the Plutchik-van Praag Depression Inventory. Results GAD patients scored highest on the Neuroticism-Anxiety trait, TRD patients scored highest on depression, and both patients scored lower on the Sociability trait. Patients with GAD also bisected lines significantly leftward compared to the healthy subjects. The Frequency of the bisection error was negatively correlated with Disinhibition-Seeking in the healthy subjects, and with Total sensation-seeking and Experience-Seeking in GAD patients, while the Magnitude of the line bisection error was negatively correlated with depression in TRD patients. Conclusions The study suggests a stronger right hemispheric activation, a weaker left activation, or both in the GAD, instead of TRD patients.