INCREASED LEVEL OF DIHYDROFOLIC REDUCTASE IN LEUCOCYTES OF PATIENTS TREATED WITH AMETHOPTERIN
INCREASED LEVEL OF DIHYDROFOLIC REDUCTASE IN LEUCOCYTES OF PATIENTS TREATED WITH AMETHOPTERIN
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DOI：
10.1038/193140a0
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发表时间：
1962-01-01
期刊：
影响因子：
64.8
通讯作者：
GABRIO, BW
中科院分区：
文献类型：
--
作者：
BERTINO, JR;HUENNEKENS, FM;GABRIO, BW
8月9月10日| Nộy。[12 .] [12 .] [footnoteref: 1] [footnoteref: 1]。化疗剂量的刻度仅指紫蝶呤。患者白细胞对其他药物的实际值为：6-巯基嘌呤，300毫克。九天；强的松，80,40和20ingm，连续三天；二氯甲蝶呤25毫克Jday（静脉注射）两天；氯霉素，2毫克。在接受紫蝶呤治疗的患者中，5天的耐药性。在一些患者使用阿霉素治疗期间，对二氢叶酸还原酶水平进行了跟踪。急性髓母细胞白血病患者的典型结果如图1所示。在这里报道的工作之前，患者在接受6-巯基嘌呤治疗后经历了部分缓解，持续了大约四个月。除了白细胞计数、治疗和还原酶水平外，还显示了另一种叶酸依赖系统甲酸激活酶的水平。在最初的紫蝶呤疗程后，白细胞计数迅速下降到3000的水平，并通过额外的化疗维持了大约三周。胃肠道毒性，如图表上垂直箭头所示，需要中断治疗。在这段部分缓解期间，爆发形式从95%减少到20%，hæ matcrit和血小板计数上升。同时，二氢-的水平增加了6倍
Aug Sept.| Ocf.| Nộy.| Dec. amethopterin _ to produce any appreciable effect indicated that Fig. 1. The scale for chemotherapeutic dosages refers only to amethopterin. Actual values the leucocytes of the patient had for the other agents were: 6-mercaptopurine, 300 mgm. jday for nine days; prednisone, 80, 40 and 20 Ingm, on three successive days; dichloroamethopterin, 25 mgm. jday (intravenous) for two days; and chloromycetin, 2 mgm./day for five days resistance in patients undergoing treatment with amethopterin. The level of dihydrofolic reductase has been followed in a number of patients during the course of treatment with amethopterin". Typical results for a patient with acute myeloblastic leukæmia are shown in Fig. 1. Before the work reported here, the patient had experienced a partial remission, lasting for about four months, on being treated with 6-mercaptopurine. In addition to white cell count, therapy and reductase-level, values are also shown for the level of formate-activating enzyme, another folic acid-dependent system. Following an initial course of amethopterin, the white count dropped rapidly to a level of 3,000 and was maintained for about three weeks with additional chemotherapy. Gastro-intestinal toxicity, as indicated by vertical arrows on the chart, necessitated the interruption of therapy. During this period of partial remission, there was a decrease in blast forms from 95 per cent to 20 per cent and a rise in the hæmatocrit and in platelet count. Concomitantly, a six-fold increase was observed in the level of dihydro-