Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging.
Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging.
复制标题
DOI：
10.1371/journal.pone.0157410
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Lee PH
中科院分区：
文献类型：
--
作者：
Hong JY;Sunwoo MK;Oh JS;Kim JS;Sohn YH;Lee PH
多巴胺转运蛋白（DAT）的功能性神经成像用于区分药物诱导的帕金森综合征（DIP）和亚临床帕金森病（PD）。尽管DAT图像正常的DIP患者有望完全康复，但有些患者却不能。我们使用18F-FP-CIT PET数据的半定量分析来研究这些患者是否显示纹状体DAT活性的变化。从医疗记录中选择DAT图像视觉正常的DIP患者。受试者分为12个月内部分恢复（PR）或完全恢复（CR）的患者。比较CR组和PR组纹状体各亚区的18F-FP-CIT摄取。CR组和PR组分别有41例和9例患者接受了评估。两组患者在临床特征方面具有可比性，包括年龄、性别和帕金森综合征的严重程度。从PET图像的半定量分析，PR患者显示腹侧纹状体，前壳核和后壳核中的配体摄取相对较低，与CR患者相比。这一结果表明，持续性DIP的患者与视觉正常的DAT成像可能与微妙的减少DAT活动。
Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish drug-induced parkinsonism (DIP) from subclinical Parkinson’s disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semi-quantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.