NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.
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DOI：
10.1016/j.celrep.2013.08.002
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发表时间：
2013-09-12
期刊：
影响因子：
8.8
通讯作者：
Marneros AG
中科院分区：
文献类型：
--
作者：
Marneros AG
The NLRP3 inflammasome is activated in age-related macular degeneration (AMD), but it remains unknown whether its activation contributes to AMD pathologies. VEGF-A is increased in neovascular (“wet”) AMD, but it is not known whether it plays a role in inflammasome activation, whether an increase of VEGF-A by itself is sufficient to cause neovascular AMD, and whether it can contribute to nonexudative (“dry”) AMD that often co-occurs with the neovascular form. Here it is shown that an increase in VEGF-A results in NLRP3 inflammasome activation and is sufficient to cause both forms of AMD pathologies. Targeting NLRP3 or the inflammasome effector cytokine IL-1β inhibits but does not prevent VEGF-A-induced AMD pathologies, while targeting IL-18 promotes AMD. Thus, increased VEGF-A provides a unifying pathomechanism for both forms of AMD; combining therapeutic inhibition of both VEGF-A and IL-1β or the NLRP3 inflammasome is therefore likely to suppress both forms of AMD.
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影响因子：
4.4
作者：
Ablonczy, Zsolt;Dahrouj, Mohammad;Crosson, Craig E.
通讯作者：
Crosson, Craig E.
影响因子：
6
作者：
He, Lizhi;Marneros, Alexander G.
通讯作者：
Marneros, Alexander G.
影响因子：
30.8
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通讯作者：
Abecasis, Goncalo R.
影响因子：
11.4
作者：
Jafarifar, Faegheh;Yao, Peng;Fox, Paul L.
通讯作者：
Fox, Paul L.
影响因子：
20.3
作者：
Cervi, David;Shaked, Yuval;Ben-David, Yaacov
通讯作者：
Ben-David, Yaacov