Antioxidant properties of Pelargonium graveolens L'Her essential oil on the reproductive damage induced by deltamethrin in mice as compared to alpha-tocopherol.
Antioxidant properties of Pelargonium graveolens L'Her essential oil on the reproductive damage induced by deltamethrin in mice as compared to alpha-tocopherol.
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DOI：
10.1186/1476-511x-12-30
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发表时间：
2013-03-07
影响因子：
4.5
通讯作者：
Gdoura R
中科院分区：
文献类型：
--
作者：
Ben Slima A;Ali MB;Barkallah M;Traore AI;Boudawara T;Allouche N;Gdoura R
暴露于拟除虫菊酯类农药溴氰菊酯已被证明对非目标生物产生广泛影响。通过研究天竺葵油是否能有效对抗溴氰菊酯引起的生殖毒性，并将其作用与维生素E（作为标准参比药物）进行比较，在经口给予溴氰菊酯（DL）的小鼠中评估了天竺葵精油（EO）作为抗氧化剂的有益作用。将60只雄性白化病小鼠分为6组：对照组，溴氰菊酯组（5 mg/kg b.w.），两组在给予天竺葵精油（67 mg/kg b.w.）或维生素E（Vit E）（100 mg/kg b.w.），两组分别给予雌二醇或维生素E。与对照组相比，5 mg/kg/天剂量的溴氰菊酯导致附睾精子计数活力和存活率降低，以及精子异常形态数量增加。与对照动物相比，DL暴露小鼠睾丸中的脂质过氧化（LPP）显著增加。天竺葵挥发油可通过降低LPP来预防睾丸氧化损伤，并改善小鼠精子的总运动力、存活力和形态。我们的研究表明，天竺葵精油对动物雄性生殖系统的积极影响与维生素E相似。
Exposure to the pyrethroid pesticide deltamethrin has been demonstrated to exert a wide range of effects on non-targeted organisms. The beneficial effects of geranuim essential oil (EO) as an antioxidant has been assessed in deltamethrin (DL) orally administered mice by studying whether the reprotoxicity caused by deltamethrin can be effectively combated with the geranium oil and the effects were compared to vitamin E, as the standard reference drug. Sixty male albino mice were divided into six equal groups: a control group, a group of mice was given deltamethrin (5 mg/kg b.w.), two groups were administered deltamethrin after having given geranium essential oil (67 mg/kg b.w.) or vitamin E (Vit E) (100 mg/kg b.w.), and two groups received only EO of geranium or Vit E. When compared to control, a dose of deltamethrin 5 mg/kg/day causes a decrease in the epididymal sperm count motility and viability and an increase in the number of abnormal morphology in spermatozoa. DL-exposed mice showed a significant increase of lipid peroxidation (LPP) in the testis compared to control animals. Essential oil of geranium prevented testicular oxidative damage explored by reduced LPP and improved total sperm motility, viability and morphology in mice spermatozoa. Our study showed a positive influence of geranium essential oil in the animal male reproductive system similar than that of Vit E.