Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes
Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes
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DOI：
10.2337/diacare.26.5.1507
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发表时间：
2003-05-01
期刊：
影响因子：
16.2
通讯作者：
Araki, E
中科院分区：
文献类型：
--
作者：
Nishikawa, T;Sasahara, T;Araki, E
目的-评估尿8-羟基脱氧鸟苷（8-OHdG）作为糖尿病大血管病变并发症进展的市场。研究设计和方法-检测96例2型糖尿病患者的尿8-OHdG含量、颈总动脉内膜中层厚度（IMT）、冠心病（CHD）风险评分、糖尿病视网膜病变严重程度和尿白蛋白排泄。包括32名被提名参加熊本研究的患者[Shichiri M等，糖尿病护理23（增刊2）B21-1329，2000]。结果：HbA（1c）升高患者的尿8-OHdG：肌酐比值（U8-OHdG）是HbA（1c）正常患者的2.5倍（P < 0.05）。此外，U8-OHdG在IMT增加的患者中高2.3倍（P < 0.005）。US-OHdG与CHD危险度评分结果相似（P < 0.01）。单纯性视网膜病变组和晚期视网膜病变组的U8-OHdG均显著高于非视网膜病变组（P < 0.05和P < 0.01）。蛋白尿组U8-OHdG明显高于正常对照组（P < 0.01）。此外，在熊本研究中，多次胰岛素注射治疗组的U8-OHdG显著低于常规胰岛素注射治疗组（P <0.00）。8-OHdG不仅是2型糖尿病患者微血管并发症的有用生物标志物，也是2型糖尿病患者大血管并发症的有用生物标志物。
OBJECTIVE - To evaluate urinary 8-hydroxydeoxyguanosine (8-OHdG)as a market for the progression of diabetic macroangicipathic complications.RESEARCH DESIGN AND METHODS - The content of urinary 8-OHdG, common carotid intima-media thickness (IMT), the coronary heart disease (CHD) risk score, the severity of diabetic retinopathy, and urinary albumin excretion were examined in 96 patients with type 2 diabetes, including 32 patients who had been nominated for the Kumamoto Study [Shichiri M, et al. Diabete Care 23 (Suppl 2) B21-1329, 2000]. In addition, the patients from the Krumamoto Study were futher evaluated regarding the effect of intensive insulin therapy on urinary 8-OHdG, excretion.RESULTS - The urinary 8-OHdG:creatinine ratio (U8-OHdG) was 2.5-fold higher in patients with increased HbA(1c) than in those with normal HbA(1c) (P < 0.05). In addition, U8-OHdG was 2.3-fold higher in patients with increased IMT (P < 0.005). A simular result was observed between US-OHdG and CHD risk score (P < 0.01). U8-OHdG was significantly higher in patients With simple retinopathy (P < 0.05) and those With advanced retinopathy (P < 0.01) than in patients Without retinopathy. Similarly, U8-OHdG Was significantly higher in patients with albuminuria (P < 0.01). Furthermore, in the Kumamoto study, U8-OHdG was significantly lower in the Multiple insulin injection therapy group compared with the conventional insulin injection therapy group (P < 0 00).CONCLUSIONS - Hyperglycemia independently increases 8-OHdG in patients with type 2 diabetes. 8-OHdG is a useful biomarker of not only microvascular but also macrovascular complications in patients with type 2 diabetes.