ANTIOXIDANT ACTION OF NATURAL HEALTH PRODUCTS AND CHINESE HERBS
ANTIOXIDANT ACTION OF NATURAL HEALTH PRODUCTS AND CHINESE HERBS
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DOI：
10.1007/bf00916043
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发表时间：
1986-03-01
期刊：
影响因子：
5.1
通讯作者：
MIYACHI, Y
中科院分区：
文献类型：
--
作者：
NIWA, Y;MIYACHI, Y
在激活的中性粒细胞和黄嘌呤-黄嘌呤氧化酶这两个体外ROS生成系统中研究了两种天然保健品、抗氧化剂类似物(AOA)和绿浆(GM)以及16种中草药对活性氧(ROS)的清除作用。天然的、未加热的 AOA 和转基因产品显着降低了 ROS 水平，而未加热的中草药对 ROS 水平的影响可以忽略不计。相比之下，热提取的中药和AOA显着抑制了两个系统中的ROS水平，而转基因则轻度抑制了这两个系统中的ROS水平。这些天然的、未加热的产品的 ROS 清除活性不受透析的影响，但加热的产品的 ROS 清除活性因透析而显着降低。此外，将这些产品与通过健康志愿者的胃管获得的胃液一起孵育显示出与通过热处理或不进行透析所诱导的结果相当的结果。尽管这些天然产物的抗氧化活性似乎部分归因于超氧化物歧化酶 (SOD) 等酶，但主要因素似乎是低分子量 ROS 清除剂，如热处理后观察到的，它们通过胃液消化释放或激活。
The scavenging effect of reactive oxygen species (ROS) by two natural health products, antioxidant analogs (AOA), and green magma (GM), and 16 medical Chinese herbs were investigted in two in vitro ROS-generating systems, activated neutrophils and xanthine-xanthine oxidase. Native, unheated AOA and GM products signifcantly reduced ROS levels, while unheated Chinese herbs had a negligible effect on ROS levels. In contrast, heat-extracted Chinese herbs and AOA markedly, and GM mildly, suppressed the levels of ROS in both systems. The ROS scavenging activity of these native, unheated products was unaffected by dialysis, but that of heated products was markedly diminished by dialysis. Further, the incubation of these products with gastric juice obtained by a gastric tube from healthy volunteers revealed results comparable to those induced by heat treatment with or without dialysis. Although the antioxidant activity of these natural products appears to be partly due to enzymes such as superoxide dismutase (SOD), the predominant factor seems to be low-molecular-weight ROS scavengers that are liberated or activated by gastric juice digestion as observed after heat treatment.