Resting-state functional connectivity alterations in periventricular nodular heterotopia related epilepsy
Resting-state functional connectivity alterations in periventricular nodular heterotopia related epilepsy
复制标题
脑室周围结节性异位相关癫痫的静息态功能连接改变
DOI：
10.1038/s41598-019-55002-3
复制
发表时间：
2019-12-05
影响因子：
4.6
通讯作者：
Gong, Qiyong
中科院分区：
文献类型：
--
作者：
Liu, Wenyu;Hu, Xinyu;Gong, Qiyong
脑室周围结节性异位是一种神经移行障碍，临床上常以癫痫发作为主要表现。然而，PNH潜在的功能神经基础仍然不清楚。我们的目的是探索潜在的病理机制PNH结合全脑功能连接（FC）和种子为基础的FC分析。我们利用静息态fMRI测量功能连接强度（FCS）在38例PNH相关癫痫患者和38名对照组。在以下FC分析中选择具有FCS改变的区域作为种子。Pearson相关分析用于探讨这些功能性神经相关物与临床特征之间的关联。与对照组相比，PNH患者双侧脑干的FCS较低（P < 0.05，FWE校正），默认模式网络的FC较高，额-边缘-小脑回路的FC较低（P < 0.05，FWE校正）。Pearson相关分析显示双侧小脑皮质FCS与癫痫持续时间呈负相关（P <0. 05），内侧前额叶-岛叶连接与汉密尔顿焦虑量表呈负相关（P <0. 05），小脑-岛叶连接与汉密尔顿抑郁量表呈负相关（P <0. 05）。使用静息态FCS分析方法，我们确定了PNH患者的显著岛叶低激活，这表明在这种情况下，小脑可能代表全脑网络的皮质中枢。此外，大规模神经网络中静息状态FC的破坏表明PNH中存在基于连通性的神经病理过程。
Periventricular nodular heterotopia (PNH) is a neural migration disorder which often presents clinically with seizures. However, the underlying functional neural basis of PNH is still unclear. We aimed to explore the underlying pathological mechanism of PNH by combining both whole brain functional connectivity (FC) and seed-based FC analyses. We utilized resting-state fMRI to measure functional connectivity strength (FCS) in 38 patients with PNH-related epilepsy and 38 control subjects. The regions with FCS alterations were selected as seeds in the following FC analyses. Pearson correlation analyses were performed to explore associations between these functional neural correlates and clinical features. In comparison with controls, PNH patients showed lower FCS in bilateral insula (P < 0.05, family wise error (FWE) correction), higher FC in the default mode network and lower FC in the fronto-limbic-cerebellar circuits (P < 0.05, FWE correction). Pearson correlation analyses revealed that FCS in bilateral insula was negatively correlated with the epilepsy duration (P < 0.05); medial prefronto-insular connectivity was negatively correlated with Hamilton Anxiety Scale (P < 0.05) and cerebellar-insular connectivity was also negatively correlated with Hamilton Depression Scale (P < 0.05). Using the resting-state FCS analytical approach, we identified significant insular hypoactivation in PNH patients, which suggests that the insula might represent the cortical hub of the whole-brain networks in this condition. Additionally, disruption of resting state FC in large-scale neural networks pointed to a connectivity-based neuropathological process in PNH.