Human papillomavirus-related multiphenotypic sinonasal carcinoma
Human papillomavirus-related multiphenotypic sinonasal carcinoma
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人乳头瘤病毒相关的多表型鼻窦癌
DOI：
10.1016/j.anl.2021.10.008
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发表时间：
2021
影响因子：
1.7
通讯作者：
Hayashi Ryuichi
中科院分区：
文献类型：
--
作者：
Morishita Yohei;Sakashita Shingo;Tomioka Toshifumi;Okano Wataru;Shinozaki Takeshi;Higashino Takuya;Matsuura Kazuto;Hayashi Ryuichi
人乳头瘤病毒相关多表型鼻窦癌(HMSC)是近年来报道的一种罕见的鼻腔鼻道原发肿瘤。据报道，它与人类乳头瘤病毒感染有关。肿瘤呈腺囊肿样组织学改变，但部分病例可见鳞状上皮化，p16免疫组织化学染色阳性。该病的临床表现和治疗方法尚未确定。然而，这篇报道描述了一例采用抢救性手术治疗的复发病例。患者是一名61岁的女性，她向前一位医生提出鼻塞的主诉。在左侧鼻腔发现一个局限性肿瘤，并在内窥镜引导下切除。术后病理诊断为骨髓间充质干细胞。术后21个月，观察局部复发，患者转诊至本院。由于复发的病变已广泛侵犯鼻腔外，因此进行了广泛切除和重建手术。术后进行放射治疗作为辅助治疗。值得注意的是，自抢救手术以来已经过去了13个月，到目前为止还没有观察到复发。
Human papillomavirus-related multiphenotypic sinonasal carcinoma (HMSC) is a rare primary tumor of the sinonasal tract that has been reported recently. It is reportedly associated with human papillomavirus infection. The tumor presents with glandular cyst-like histology, but some cases exhibit squamous epithelialization and are positive on p16 immunohistochemical staining. The clinical picture and treatment of this disease have not been established. However, this report describes a recurrent case of this disease treated with salvage surgery. The patient was a 61-year-old woman who presented to the previous doctor with a chief complaint of nasal obstruction. A localized tumor was found in the left nasal cavity and was resected under endoscopic guidance. The postoperative pathological diagnosis was HMSC. Twenty-one months after the surgery, local recurrence was observed, and the patient was referred to our hospital. Since the recurrent lesion had widely infiltrated outside the nasal cavity, extensive resection and reconstructive surgery were performed. Postoperative radiotherapy was performed as an additional treatment. Notably, 13 months have passed since the salvage surgery, and no recurrence has been observed to date.