Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.
Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy.
复制标题
当前了解亚硝酸盐作为一氧化氮生物学和治疗中不可或缺的角色的观点和挑战。
DOI：
10.1016/j.freeradbiomed.2011.05.037
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发表时间：
2011
影响因子：
7.4
通讯作者：
Patel,RakeshP
中科院分区：
文献类型：
--
作者：
Vitturi,DarioA;Patel,RakeshP
除了一氧化氮 (NO) 代谢的惰性氧化产物之外，目前的观点还认为亚硝酸盐作为 NO 信号传导介质发挥着关键作用，尤其是在缺氧期间。这个概念已经在亚硝酸盐作为 NO 稳态内源性调节剂的背景下进行了讨论，而且还从新的临床角度进行了讨论，即亚硝酸盐治疗可以补充 NO 信号传导并预防缺血性组织损伤。事实上，描述作用机制的研究相对快速地转化为正在进行的和计划中的临床试验对于激发人们对亚硝酸盐生物学的兴趣至关重要，并且已经就此主题撰写了几篇精彩的评论。在本文中，我们的讨论仅限于当前的概念，以及我们认为在亚硝酸盐作为一氧化氮生物学介质的范式中仍未得到解答的问题。
Beyond an inert oxidation product of nitric oxide (NO) metabolism, current thinking posits a key role for nitrite as a mediator of NO signaling, especially during hypoxia. This concept has been discussed in the context of nitrite serving a role as an endogenous modulator of NO homeostasis, but also from a novel clinical perspective whereby nitrite therapy may replenish NO signaling and prevent ischemic tissue injury. Indeed, the relatively rapid translation of studies delineating mechanisms of action to ongoing and planned clinical trials has been critical in fuelling interest in nitrite biology, and several excellent reviews have been written on this topic. In this article we limit our discussions to current concepts and what we feel are questions that remain unanswered within the paradigm of nitrite being a mediator of NO biology.