BACTERICIDAL ACTIVITY INVITRO OF VARIOUS RIFAMYCINS AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS
BACTERICIDAL ACTIVITY INVITRO OF VARIOUS RIFAMYCINS AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS
复制标题
DOI：
10.1164/ajrccm/141.3.626
复制
发表时间：
1990-03-01
期刊：
影响因子：
--
通讯作者：
FLORY, MA
中科院分区：
文献类型：
--
作者：
HEIFETS, LB;LINDHOLMLEVY, PJ;FLORY, MA
测定了50 M利福平（RMP）、利福朋（RBT）、利福喷丁（RPT）、CGP-7040和P-DEA的最小抑菌浓度和杀菌浓度（MIC和MBC）。7H12液体培养基在不同pH条件下进行放射性测定。其中一半来自艾滋病患者，另一半来自没有艾滋病但患有肺部疾病的患者。还在7H12肉汤中测定了M的MIC和MBC。结核菌株用M.结核菌株和人血清峰值水平用作解释利福霉素对M的MIC和MBC的标准。avium所有利福霉素对M. avium显著低于M.结核大多数M。禽流感病毒株属于"易感"类别，例如，与敏感M.当用CGP-7040和RPT测试时，所有的结核菌株都是“中度敏感的”，当用P-DEA测试时，所有的结核菌株都是“中度敏感的”。在体外抑菌和杀菌活性的基础上，RPT、P-DEA和CGP-7040这三种药物似乎比RMP和RBT对M.禽流感
Minimal inhibitory and bactericidal concentrations (MICs and MBCs) of rifampin (RMP), rifabutin (RBT), rifapentine (RPT), CGP-7040, and P-DEA, were determined for 50 M. avium strains in 7H12 liquid medium radiometrically under various pH conditions. Half were isolated from patients with AIDS and the other half from patients without AIDS but with pulmonary disease. The MICs and MBCs were also determined in 7H12 broth for M. tuberculosis strains. The MIC results obtained with M. tuberculosis strains, and the serum peak levels in humans, were used as standards for interpretation of the MICs and MBCs of the rifamycins for M. avium. The bactericidal activity of all rifamycins for M. avium was substantially lower than for M. tuberculosis. The majority of M. avium strains was within the "susceptible" category, e.g., comparable to susceptible M. tuberculosis strains, when tested with CGP-7040 and RPT, and all of them were "moderately susceptible" when tested with P-DEA. On the basis of in vitro bacteriostatic and bactericidal activity, it seems that three agents, RPT, P-DEA, and CGP-7040 have more potential than do RMP and RBT against M. avium disease.