Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein.
Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein.
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sp56（一种小鼠精子受精蛋白）的组织和物种特异性表达。
DOI：
10.1126/science.7604284
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Bleil,JD
中科院分区：
文献类型：
--
作者：
Bookbinder,LH;Cheng,A;Bleil,JD
小鼠精子识别并结合ZP3，ZP3是卵子透明质膜中的三种糖蛋白之一。一种小鼠精子蛋白，sp56，被鉴定为具有预期的负责识别ZP3的精子蛋白的特征。分离编码sp56的互补DNA，其一级序列表明sp56是蛋白受体超家族的成员。研究表明，sp56的表达仅限于小鼠精子细胞，不同物种精子上sp56的存在或不存在说明了小鼠精卵识别的物种特异性。
Mouse sperm recognize and bind to ZP3, one of three glycoproteins in the egg's zona pellucida. A mouse sperm protein, sp56, was identified that has the characteristics expected of the sperm protein responsible for recognition of ZP3. The complementary DNA encoding sp56 was isolated, and its primary sequence indicates that sp56 is a member of a superfamily of protein receptors. It was shown that sp56 expression is restricted to mouse spermatids and that the presence or absence of sp56 on sperm from different species accounts for species specificity of sperm-egg recognition in mice.