Bone reaction to nano hydroxyapatite modified titanium implants placed in a gap-healing model
Bone reaction to nano hydroxyapatite modified titanium implants placed in a gap-healing model
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DOI：
10.1002/jbm.a.31736
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发表时间：
2008-12-01
影响因子：
4.9
通讯作者：
Wennerberg, Ann
中科院分区：
文献类型：
--
作者：
Meirelles, Luiz;Albrektsson, Tomas;Wennerberg, Ann
纳米羟基磷灰石材料显示出与骨磷灰石相似的化学性质，并且取决于底层形貌和制备方法，纳米羟基磷灰石可以模拟骨中晶体的特定排列。羟基磷灰石（HA）和其他CaP材料适用于手术过程中无法实现最佳手术配合的情况，HA表面特性可增强缺损区域的骨填充。在这项研究中，非常光滑的电解抛光钛种植体被用作纳米HA表面改性的基底，并作为对照。将每种植入物（对照和纳米HA）中的一种植入物置于家兔胫骨中，手术部位比植入物直径宽0.7 mm，导致植入物每侧的间隙为0.35 mm。通过用两侧螺钉固定的固定板确保植入物稳定性。用光学干涉仪进行的形貌评估显示，两种植入物上都没有微结构，用AFM进行的更高分辨率评估显示出相似的纳米粗糙度参数。在AFM测量上检测到的表面孔具有相似的直径、深度和表面孔隙率（%）。组织学评价表明，愈合4周后，纳米HA和电抛光种植体的骨形成相似。这些结果并不支持纳米HA化学和纳米形貌将增强骨形成时，放置在间隙愈合模型。非常光滑的表面可能阻止了材料的最佳活性，未来的研究可能会评估表面化学，微观和纳米形貌的协同效应，为它们中的每一个建立最佳参数。(C)2008 Wiley Periodicals，Inc. J Biomed Mater Res 87A：624-631，2008
Nanohydroxyapatite materials show similar chemistry to the bone apatite and depending on the underlying topography and the method of preparation, the nanohydroxyapatite may simulate the specific arrangement of the crystals in bone. Hydroxyapatite (HA) and other CaP materials have been indicated in cases in which the optimal surgical fit is not achievable during surgery, and the HA surface properties may enhance bone filling of the defect area. In this study, very smooth electropolished titanium implants were used as substrata for nano-HA surface modification and as control. One of each implant (control and nano HA) was placed in the rabbit tibia in a surgical site 0.7 mm wider than the implant diameter, resulting in a gap of 0.35 mm on each implant side. Implant stability was ensured by a fixating plate fastened with two side screws. Topographical evaluation performed with an optical interferometer revealed the absence of microstructures on both implants and higher resolution evaluation with AFM showed similar nanoroughness parameters. Surface pores detected on the AFM measurements had similar diameter, depth, and surface porosity (%). Histological evaluation demonstrated similar bone formation for the nano HA and electropolished implants after 4 weeks of healing. These results do not support that nano-HA chemistry and nanotopography will enhance bone formation when placed in a gap-healing model. The very smooth surface may have prevented optimal activity of the material and future studies may evaluate the synergic effects of the surface chemistry, micro, and nanotopography, establishing the optimal parameters for each of them. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 87A: 624-631, 2008