Toward a mechanistic explanation of phenotypic evolution: The need for a theory of theory integration
Toward a mechanistic explanation of phenotypic evolution: The need for a theory of theory integration
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对表型进化的机械解释：需要理论整合理论
DOI：
10.1002/jez.b.22785
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Stadler, Peter F.
中科院分区：
文献类型：
--
作者：
Laubichler, Manfred D.;Prohaska, Sonja J.;Stadler, Peter F.
调和不同的潜在本体和解释背景一直是生物学理论整合的主要挑战和障碍之一。在这里，我们分析了发展一个包容和整合的表型进化理论的挑战，作为在生命科学中发展理论整合理论的更广泛挑战的一个例子，并提出了一些必要的正式步骤，以解决经常不相容（隐藏）的假设。生物学的理论整合需要对生物学理论的结构有更好的形式化的理解，整合理论的策略关键取决于底层本体的关系。
Reconciling different underlying ontologies and explanatory contexts has been one of the main challenges and impediments for theory integration in biology. Here, we analyze the challenge of developing an inclusive and integrative theory of phenotypic evolution as an example for the broader challenge of developing a theory of theory integration within the life sciences and suggest a number of necessary formal steps toward the resolution of often incompatible (hidden) assumptions. Theory integration in biology requires a better formal understanding of the structure of biological theories The strategy for integrating theories crucially depends on the relationships of the underlying ontologies.