Relationship Between Speed of Sound in and Density of Normal and Diseased Rat Livers
Relationship Between Speed of Sound in and Density of Normal and Diseased Rat Livers
复制标题
正常和患病大鼠肝脏中的声速与密度之间的关系
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Motonao Tanaka
中科院分区：
文献类型：
--
作者：
H. Hachiya;S. Ohtsuki;Motonao Tanaka
声速是生物组织定量表征的一个重要声学参数。本文研究了超声在大鼠肝组织中传播的速度与密度的关系。通过基于3.5 MHz脉冲响应的频率-时间分析的不变形技术测量声速。正常肝脏中的声速在个体之间变化最小，并且与体重或年龄无关。在给予CCl 4的肝组织中，声速低于正常组织中的声速。在正常、脂肪和硬化肝脏中声速和密度之间的关系可以很好地拟合在使用不混溶液体模型估计的线上，假设正常肝脏和脂肪组织的混合物。对于3.5 MHz超声，认为脂肪变性的新鲜肝脏中的声速与脂肪含量有关，并且不强烈依赖于纤维化程度。
Speed of sound is an important acoustic parameter for quantitative characterization of living tissues. In this paper, the relationship between speed of sound in and density of rat liver tissues are investigated. The speed of sound was measured by the nondeformable technique based on frequency-time analysis of a 3.5 MHz pulse response. The speed of sound in normal livers varied minimally between individuals and was not related to body weight or age. In liver tissues which were administered CCl4, the speed of sound was lower than the speed of sound in normal tissues. The relationship between speed of sound and density in normal, fatty and cirrhotic livers can be fitted well on the line which is estimated using the immiscible liquid model assuming a mixture of normal liver and fat tissues. For 3.5 MHz ultrasound, it is considered that the speed of sound in fresh liver with fatty degeneration is responsible for the fat content and is not strongly dependent on the degree of fibrosis.