Renal function during chronic anemia in the ovine fetus.
Renal function during chronic anemia in the ovine fetus.
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绵羊胎儿慢性贫血期间的肾功能。
DOI：
10.1152/ajpregu.1994.266.6.r1759
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Woods,LL
中科院分区：
文献类型：
--
作者：
Davis,LE;Hohimer,AR;Woods,LL
我们的目的是确定长期贫血如何改变胎儿肾功能和酸碱平衡。在连续等容性出血1周以上造成进行性贫血的7只羊胎中，红细胞压积从33.3 +/- 4.5降至14.0 +/-1.0%。与6只对照胎仔（7.0 +/- 1.3 ml/dl和160 +/- 34 ml.min-1.100 g kidney-1）相比，贫血胎仔（1.5 +/- 0.1 ml/dl和339 +/- 58 ml. min-1.100 g kidney-1）的股动脉氧含量较低，肾血浆流量较高。贫血胎儿的尿流量和钠排泄量（1.2 +/- 0.6 ml/min和79 +/- 49.5 mumol/min）也高于对照组（0.5 +/- 0.2 ml/min和16 +/- 9.8 mumol/min）。这种较高的钠排泄显然是由于与对照组相比，贫血胎儿的钠重吸收分数较低（84.1 +/- 5.8 vs. 96.5 +/- 1.7%），而不是由于肾小球滤过率或滤过钠量的差异。此外，与对照组相比，贫血胎儿的钠排泄量更高与尿乳酸盐和无机磷酸盐排泄量更高以及羊水量更大有关。从这些数据中，我们得出结论，当胎儿肾氧输送受到血细胞比容长期降低的限制时，钠和水以及其他促排活性溶质的排泄增加，这导致羊水量增加。
Our purpose was to determine how prolonged anemia alters fetal renal function and acid-base balance. In seven ovine fetuses made progressively anemic over 1 wk by serial isovolemic hemorrhage, hematocrit was reduced from 33.3 +/- 4.5 to 14.0 +/- 1.0%. Femoral arterial oxygen content was less and renal plasma flow was greater in anemic fetuses (1.5 +/- 0.1 ml/dl and 339 +/- 58 ml.min-1.100 g kidney-1) than in 6 control fetuses (7.0 +/- 1.3 ml/dl and 160 +/- 34 ml.min-1.100 g kidney-1). Urine flow and sodium excretion were also greater in anemic fetuses (1.2 +/- 0.6 ml/min and 79 +/- 49.5 mumol/min) than in controls (0.5 +/- 0.2 ml/min and 16 +/- 9.8 mumol/min). This higher sodium excretion was apparently due to a lower fractional sodium reabsorption in anemic fetuses compared with controls (84.1 +/- 5.8 vs. 96.5 +/- 1.7%), rather than to differences in either glomerular filtration rate or amount of filtered sodium. In addition, the higher sodium excretion in anemic fetuses was associated with greater urinary lactate and inorganic phosphate excretions and larger amniotic fluid volumes than in controls. From these data we conclude that when fetal renal oxygen delivery is limited by a prolonged reduction in hematocrit, excretions of sodium and water, as well as other osmotically active solutes, increase, and this results in an increase in amniotic fluid volume.