Functional interactions between dendritic cells and NK cells during viral infection
Functional interactions between dendritic cells and NK cells during viral infection
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DOI：
10.1038/ni880
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发表时间：
2003-02-01
影响因子：
30.5
通讯作者：
Degli-Esposti, MA
中科院分区：
文献类型：
--
作者：
Andrews, DM;Scalzo, AA;Degli-Esposti, MA
Ly 49 H（+）NK1.1（+）自然杀伤（NK）细胞在小鼠巨细胞病毒（MCMV）感染急性期的控制中是必不可少的。该细胞亚群在感染的后期以MCMV特异性方式扩增。在这里，我们证明了Ly 49 H（+）NK细胞和CD 8 α（+）树突状细胞（DC）之间的关键相互作用，由此Ly 49 H（+）NK细胞的存在导致急性MCMV感染期间脾脏中CD 8 α（+）DC的维持。反过来，CD 8 α（+）DC通过涉及白细胞介素18（IL-18）和IL-12的机制对Ly 49 H（+）NK细胞的扩增至关重要。本研究为病毒感染过程中DC和NK细胞之间的功能相互关系提供了证据，并定义了一些关键的细胞因子。
Ly49H(+)NK1.1(+) natural killer (NK) cells are essential for the control of murine cytomegalovirus (MCMV) during the acute stage of infection. This cell subset expands at the later stages of infection in an MCMV-specific fashion. Here we demonstrate a critical interaction between Ly49H(+) NK cells and CD8alpha(+) dendritic cells (DCs) whereby the presence of Ly49H(+) NK cells results in maintenance of CD8alpha(+) DCs in the spleen during acute MCMV infection. Reciprocally, CD8alpha(+) DCs are essential for the expansion of Ly49H(+) NK cells by a mechanism involving interleukin 18 (IL-18) and IL-12. This study provides evidence for a functional interrelationship between DCs and NK cells during viral infection and defines some of the critical cytokines.