Molecularly Imprinted Antibiotic Receptor on Magnetic Nanotube for Detection and Removal of Environmental Oxytetracycline
Molecularly Imprinted Antibiotic Receptor on Magnetic Nanotube for Detection and Removal of Environmental Oxytetracycline
复制标题
磁性纳米管上的分子印迹抗生素受体用于检测和去除环境土霉素
DOI：
10.1039/d2tb00497f
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发表时间：
2022
影响因子：
7
通讯作者：
Hongbo Zhang
中科院分区：
文献类型：
--
作者：
Jixiang Wang;Xiaolei Li;Rong Zhang;Bingjie Fu;Mingcan Chen;Mengxue Ye;Wanyu Liu;Jingjing Xu;Guoqing Pan;Hongbo Zhang
检测和消除抗生素污染物，如土霉素（OTC），一种广谱四环素抗生素，将有助于有效的环境监测，农业和食品安全测试。然而，目前可用的方法，主要依赖于色谱分离的土霉素，遭受低灵敏度和复杂的过程。因此，我们在这里报告的设计和合成的荧光传感器的基础上分子印迹磁性埃洛石纳米管（简称MHNTs@ FMIP）的有效检测和实际环境样品中的土霉素的纯化。土霉素对MHNTs@FMIPs的荧光有明显的猝灭作用，线性范围为10-300 nM，检测限（LOD）低至8.1 nM。印迹因子为4.47，表明具有良好的特异性。此外，MHNTs@FMIPs可用于水产养殖废水和长江水体中土霉素的定量检测（5个循环，每次300 nM），显示了其巨大的应用潜力。
The detection and elimination of antibiotic contaminants, such as oxytetracycline (OTC), a broad-spectrum tetracycline antibiotic, would be of help in efficient environmental monitoring, agriculture and food safety tests. Nevertheless, currently available methodologies, which mostly rely on the chromatographic separation of OTC, suffer from low sensitivity and complicated processes. Thus, we report here on the design and synthesis of a fluorescent sensor based on molecularly imprinted magnetic halloysite nanotubes (referred to as MHNTs@FMIPs) for the effective detection and purification of OTC in actual environmental samples. The fluorescence of the MHNTs@FMIPs was quenched obviously upon loading with OTC, covering a linear concentration range of 10-300 nM with a limit of detection (LOD) as low as 8.1 nM. The imprinting factor is 4.47, indicating an excellent specificity. Furthermore, the MHNTs@FMIPs can be applied to the quantitative detection of OTC (5 cycles of 300 nM) in aquaculture wastewater and Yangtze River water, demonstrating their immense application potential.