Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations.
Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations.
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DOI：
10.1007/s12350-014-9916-2
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发表时间：
2014-10
影响因子：
2.4
通讯作者：
Kinuya, Seigo
中科院分区：
文献类型：
--
作者：
Nakajima, Kenichi;Okuda, Koichi;Yoshimura, Mana;Matsuo, Shinro;Wakabayashi, Hiroshi;Imanishi, Yasuhiro;Kinuya, Seigo
关键词：
123 I-间碘苄胍（MIBG）的心脏-纵隔比（HMR）在不同机构之间存在差异，需要在各种准直器-准直器组合之间进行标准化。在84个单位共进行了225次体模实验，计算了HMR的交叉校准系数。基于体模研究，创建了每个相机-准直器系统的转换系数，包括低能量（LE，n = 125）和中等能量（ME，n = 100）准直器。使用最常见ME组的平均转换系数计算标准HMR。在来自三个机构的临床MIBG研究（n = 52）中，对LE型和ME型准直器的HMR进行了标准化，并将其分为<1.60、1.60-2.19和≥2.20的风险组。从单个摄像机-准直器条件到数学计算的参考HMR的平均转换系数范围为LE组的0.55至0.75，ME组的0.83至0.95。使用0.88的转换系数来统一来自所有采集条件的HMR。使用标准化HMR，临床研究（n = 52）显示LE和ME类型在三个风险组之间具有良好的一致性（κ = 0.83，P <0.0001，90%的患者完全一致，42%的患者重新分类为相同的风险组）。通过使用系统的参考HMR和转换系数，具有各种条件的HMR可以转换为正常到低HMR范围内的标准HMR。
The heart-to-mediastinum ratio (HMR) of 123I-metaiodobenzylguanidine (MIBG) showed variations among institutions and needs to be standardized among various scinticamera-collimator combinations. A total of 225 phantom experiments were performed in 84 institutions to calculate cross-calibration coefficients of HMR. Based on phantom studies, a conversion coefficient for each camera-collimator system was created, including low-energy (LE, n = 125) and a medium-energy (ME, n = 100) collimators. An average conversion coefficient from the most common ME group was used to calculate the standard HMR. In clinical MIBG studies (n = 52) from three institutions, HMRs were standardized from both LE- and ME-type collimators and classified into risk groups of <1.60, 1.60-2.19, and ≥2.20. The average conversion coefficients from the individual camera-collimator condition to the mathematically calculated reference HMR ranged from 0.55 to 0.75 for LE groups and from 0.83 to 0.95 for ME groups. The conversion coefficient of 0.88 was used to unify HMRs from all acquisition conditions. Using the standardized HMR, clinical studies (n = 52) showed good agreement between LE and ME types regarding three risk groups (κ = 0.83, P < .0001, complete agreement in 90%, 42% of the patients reclassified into the same risk group). By using the reference HMR and conversion coefficients for the system, HMRs with various conditions can be converted to the standard HMRs in a range of normal to low HMRs.
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影响因子：
2.4
作者：
Nakajima, Kenichi;Matsubara, Kosuke;Kinuya, Seigo
通讯作者：
Kinuya, Seigo
影响因子：
1.5
作者：
Chen, Ji;Garcia, Ernest V.;Carrio, Ignasi
通讯作者：
Carrio, Ignasi
DOI：
10.1007/s00259-014-2759-x
发表时间：
2014-09-01
影响因子：
9.1
作者：
Nakajima, Kenichi;Nakata, Tomoaki;Jacobson, Arnold F.
通讯作者：
Jacobson, Arnold F.
影响因子：
8.6
作者：
King, Alisha E.;Mintz, Jim;Royall, Donald R.
通讯作者：
Royall, Donald R.
DOI：
10.1007/s00259-005-1810-3
发表时间：
2005-09-01
影响因子：
9.1
作者：
Verberne, HJ;Feenstra, C;Sokole, EB
通讯作者：
Sokole, EB