Shaping of biological tubes by mechanical interaction of cell and extracellular matrix
Shaping of biological tubes by mechanical interaction of cell and extracellular matrix
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DOI：
10.1016/j.gde.2015.02.009
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发表时间：
2015-06-01
影响因子：
4
通讯作者：
Hayashi, Shigeo
中科院分区：
文献类型：
--
作者：
Dong, Bo;Hayashi, Shigeo
生物管的形状经过优化，可支持液体和气体的有效循环并维持有机体内平衡。保持恒定的管直径和使管长度适合身体尺寸是管正常功能的两个要求。果蝇胚胎的气管系统是在没有环境空气的情况下通过外胚层上皮的分支建立的，并且该系统的分支模式和几何形状是基因指定的。最近的研究发现心尖细胞外基质（aECM）是管扩张和伸长的关键调节因子。有证据表明，aECM 协调顶膜生长和细胞收缩性，以在组织水平上控制管生长。在本综述中，我们将讨论这种相互作用背后的物理机制。
The shape of biological tubes is optimized for supporting efficient circulation of liquid and gas and to maintain organismal homeostasis. Maintaining a constant tube diameter and fitting tube length to body size are two requirements for proper tube function. The tracheal system of the Drosophila embryo is established through branching of ectodermal epithelia in the absence of environmental air, and the branching pattern and geometry of this system are genetically specified. Recent studies identified apical extracellular matrix (aECM) as a crucial regulator of tube expansion and elongation. Evidence suggests that aECM coordinates apical membrane growth and cell contractility to control tube growth at the tissue level. In the present review, we will discuss the physical mechanisms underlying this interaction.