Surface modification of Ti-6Al-4V alloy for biomineralization and specific biological response: Part I, inorganic modification
Surface modification of Ti-6Al-4V alloy for biomineralization and specific biological response: Part I, inorganic modification
复制标题
DOI：
10.1007/s10856-011-4246-2
复制
发表时间：
2011-03-01
影响因子：
3.7
通讯作者：
Verne, E.
中科院分区：
文献类型：
--
作者：
Ferraris, S.;Spriano, S.;Verne, E.
钛及其合金代表了骨科和牙科修复器械的黄金标准，因为它们具有良好的机械性能和生物相容性。最近的研究集中在表面处理，旨在促进他们的快速骨整合，也在骨质差的情况下。本文研究了一种新的表面处理方法，以提高钛基种植体的组织整合性。表面处理能够诱导生物活性行为，而无需引入涂层，并保持Ti6Al4V基材的机械性能（抗疲劳性）。所提出的技术的应用结果在一个复杂的表面形貌，其特征在于由微观粗糙度和纳米纹理的组合，它可以耦合到传统的宏观粗糙度引起的爆破。改性的金属表面富含羟基：这一特征对于无机生物活性（体外和体内磷灰石沉淀）以及进一步的功能化过程（生物分子的接枝）极其重要。在模拟体液（SBF）中浸泡15天后，改性Ti6Al4V诱导羟基磷灰石沉淀。该工艺经过优化，以避免在表面上产生裂纹或损坏。表面氧化层呈现高耐刮擦性。
Titanium and its alloys represent the gold standard for orthopaedic and dental prosthetic devices, because of their good mechanical properties and biocompatibility. Recent research has been focused on surface treatments designed to promote their rapid osteointegration also in case of poor bone quality. A new surface treatment has been investigated in this research work, in order to improve tissue integration of titanium based implants. The surface treatment is able to induce a bioactive behaviour, without the introduction of a coating, and preserving mechanical properties of Ti6Al4V substrates (fatigue resistance). The application of the proposed technique results in a complex surface topography, characterized by the combination of a micro-roughness and a nanotexture, which can be coupled with the conventional macro-roughness induced by blasting. Modified metallic surfaces are rich in hydroxyls groups: this feature is extremely important for inorganic bioactivity (in vitro and in vivo apatite precipitation) and also for further functionalization procedures (grafting of biomolecules). Modified Ti6Al4V induced hydroxyapatite precipitation after 15 days soaking in simulated body fluid (SBF). The process was optimised in order to not induce cracks or damages on the surface. The surface oxide layer presents high scratch resistance.