Increased CSF HVA response to arecoline challenge in Alzheimer's disease
Increased CSF HVA response to arecoline challenge in Alzheimer's disease
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DOI：
10.1007/bf01250518
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
N. Pomara;M. Stanley;P. LeWitt;M. Galloway;R. Singh;D. Deptula
中科院分区：
文献类型：
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作者：
N. Pomara;M. Stanley;P. LeWitt;M. Galloway;R. Singh;D. Deptula
研究了毒蕈碱激动剂槟榔碱对阿尔茨海默病（AD）患者和对照组脑脊液中高香草酸（HVA）浓度的影响。患者和对照组接受槟榔碱静脉输注，并在输注开始后4小时进行腰椎穿刺。槟榔碱诱导阿尔茨海默病患者脑脊液中HVA浓度显著增加（p<0.01），但在对照组中没有。阿尔茨海默病中对毒蕈碱激动剂的不同HVA反应提示毒蕈碱受体反应的改变。这一发现可能对阿尔茨海默病的病理生理学和治疗有潜在的意义。
The effects of the muscarinic agonist, arecoline, on the concentration of homovanillic acid (HVA) in the cerebrospinal fluid of patients with Alzheimer's disease (AD) and controls were examined. Patients and controls received intravenous infusions of arecoline and a lumbar puncture was performed four hours after the infusion began. Arecoline induced a significant increase in the concentration of HVA in cerebrospinal fluid of Alzheimer's disease patients (p<.01) but not in controls. The differential HVA response to a muscarinic agonist in Alzheimer's disease is suggestive of an alteration in muscarinic receptor response. This finding may have potential implications for the pathophysiology and treatment of Alzheimer's disease.