Female sex and younger age are associated with hidradenitis suppurativa diagnostic delay.
Female sex and younger age are associated with hidradenitis suppurativa diagnostic delay.
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DOI：
10.1097/jw9.0000000000000114
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发表时间：
2023-12
影响因子：
--
通讯作者：
Naik, Haley B
中科院分区：
文献类型：
--
作者：
Rinderknecht, Fatuma-Ayaan B;Naik, Haley B
化脓性汗腺炎(HS)是一种慢性炎症性皮肤病。从出现症状到诊断的时间--称为诊断延迟--平均为7-10年。1诊断延误可能会延误改变病程的治疗和合并症处理。我们进行了一项横断面研究，以确定人口统计学特征是否与HS诊断延迟有关。我们回顾了2016年5月至2022年12月在单一中心接受治疗的HS患者的医疗记录。符合条件的参与者至少有2个HS ICD代码。收集了性别、种族、居住邮政编码、自我报告HS症状开始日期的年龄和诊断的数据。居住邮政编码与可公开获得的美国政府数据相关联，以按人口普查地区和每个县的皮肤科医生数量估算收入中位数。使用中位数和四分位数范围和频率对数据进行汇总。我们使用单变量线性回归模型来估计人口统计特征和诊断延迟之间的关联。对单因素分析中显著水平的特征构建了多变量模型。在514名HS患者中，有431名有完整的人口学数据，他们是不同种族的，大多数是女性。(表1)发病时的中位年龄(四分位数范围)为18岁(14，26)。中位诊断延迟时间为5年(1、10年)。单因素分析中，年龄与诊断延迟呈负相关(Coff=−0.22[−0.30，−0.15]，P<；多因素分析(Coff=−0.21[−0.28，−0.13]，P<；001)。在单因素分析中，男性患者的诊断延迟时间为2年，而女性患者为5年(Coff=2.79[0.88，4.70]，P=0.05)。多因素分析(Coff=1.91[−=0.03，3.85]，P=0.00)。05)。白人患者比非白人患者有更长的诊断延迟(白人5年，黑人：3，亚裔：3，西班牙裔/拉丁裔：5)，然而，这种差异并不显著(表2)。
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease. The time from onset of symptoms to diagnosis-termed diagnostic delay-is 7–10 years on average. 1 Diagnostic delay may delay disease course-altering treatments and comorbidity management. We conducted a cross-sectional study to determine if demographic characteristics are associated with HS diagnostic delay.We retrospectively reviewed the medical records of HS patients treated at a single center from May 2016 and December 2022. Eligible participants had at least 2 HS ICD codes. Data on sex, race, residence zip code, age at the self-reported date of HS symptom onset, and diagnosis were collected. Residence zip code was linked to publicly available US government data to approximate median income by census tract and number of dermatologists per county. Data were summarized using medians and interquartile ranges and frequencies. We used univariate linear regression models to estimate associations between demographic characteristics and diagnostic delay. A multivariable model was constructed from characteristics significant at the 0.05 level in univariate analysis. Complete demographic data were available for 431 of 514 HS patients who were racially diverse and majority female.(Table 1) Median (interquartile ranges) age at onset was 18 years (14, 26). Median diagnostic delay was 5 years (1, 10). Age was inversely associated with diagnostic delay in univariate analysis (coeff=− 0.22 [− 0.30,− 0.15], P<. 001) and multivariate analysis (coeff=− 0.21 [− 0.28,− 0.13], P<. 001). Male patients had a diagnostic delay of 2 years compared to 5 years for female patients in univariate (coeff= 2.79 [0.88, 4.70], P=. 004) and multivariate analysis (coeff= 1.91 [− 0.03, 3.85], P=. 05). White patients had longer diagnostic delays than nonwhite patients (White 5 years, Black: 3, Asian: 3, Hispanic/Latino: 5), however, this difference was not significant (Table 2).