The Effects of Diabetic Retinopathy Stage and Light Flicker on Inner Retinal Oxygen Extraction Fraction
The Effects of Diabetic Retinopathy Stage and Light Flicker on Inner Retinal Oxygen Extraction Fraction
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DOI：
10.1167/iovs.16-20048
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Shahidi, Mahnaz
中科院分区：
文献类型：
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作者：
Felder, Anthony E.;Wanek, Justin;Shahidi, Mahnaz
PURPOSE. We determined the effects of light flicker and diabetic retinopathy (DR) stage on retinal vascular diameter (D), oxygen saturation (SO2), and inner retinal oxygen extraction fraction (OEF).METHODS. Subjects were categorized as nondiabetic control (NC, n = 42), diabetic with no clinical DR (NDR; n = 32), nonproliferative DR (NPDR; n = 42), or proliferative DR (PDR; n = 14). Our customized optical imaging system simultaneously measured arterial and venous D (D-A, D-V) and SO2 (SO2A, SO2V) before and during light flicker. Inner retinal OEF was derived from SO2 values. Light flicker-induced ratios of metrics (DAR, DVR, SO2AR, SO2VR, OEFR) were calculated.RESULTS. Arterial D was larger in NPDR compared to NC (P = 0.01) and PDR (P = 0.002), whereas D-V was similar among groups (P >= 0.16). Light flicker increased D-A and D-V (P = 0.09). Arterial SO2 was higher in all groups compared to NC (P
