The Role of Interneuron Networks in Driving Human Motor Cortical Plasticity
The Role of Interneuron Networks in Driving Human Motor Cortical Plasticity
复制标题
神经元网络在驱动人类运动皮层可塑性中的作用
DOI：
10.1093/cercor/bhs147
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发表时间：
2013-07-01
期刊：
影响因子：
3.7
通讯作者：
Rothwelll, John C.
中科院分区：
文献类型：
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作者：
Hamada, Masashi;Murase, Nagako;Rothwelll, John C.
重复经颅磁刺激 (rTMS) 的后遗症因人而异。由于不同的人在不同的时间，不同的皮质神经元群体更容易受到刺激或更容易兴奋，因此这种变异性可能不是由于个体之间皮质突触可塑性的差异，而可能是由于皮质神经元募集的个体差异。在这项研究中，我们检查了 rTMS 对 56 名健康志愿者的影响。个体之间对兴奋性和抑制性 θ 爆发刺激 (TBS) 方案的反应差异很大。令人惊讶的是，TBS 效应与 TMS 脉冲诱发的运动诱发电位 (MEP) 的潜伏期高度相关，TMS 脉冲诱导穿过中央沟的前后 (AP) 定向电流。最后，我们设计了一种新的可塑性协议，使用跨中央沟的紧密定时的相反方向的 TMS 电流脉冲对。同样，后遗症与 AP 电流引起的 MEP 的潜伏期有关。我们的结果与以下观点一致：对 rTMS 可塑性探测协议的响应变化受到 TMS 脉冲招募的中间神经元网络的强烈影响。
The after-effects of repetitive transcranial magnetic stimulation (rTMS) are highly variable between individuals. Because different populations of cortical neurons are stimulated more easily or are more excitable in different people at different times, the variability may not be due to differences between individuals in the plasticity of cortical synapses, but may instead be due to individual differences in the recruitment of cortical neurons. In this study, we examined the effects of rTMS in 56 healthy volunteers. The responses to excitatory and inhibitory theta burst stimulation (TBS) protocols were highly variable between individuals. Surprisingly, the TBS effect was highly correlated with the latency of motor-evoked potentials (MEPs) evoked by TMS pulses that induced an anterior-posterior (AP) directed current across the central sulcus. Finally, we devised a new plasticity protocol using closely timed pairs of oppositely directed TMS current pulses across the central sulcus. Again, the after-effects were related to the latency of MEPs evoked by AP current. Our results are consistent with the idea that variation in response to rTMS plasticity probing protocols is strongly influenced by which interneuron networks are recruited by the TMS pulse.