Oscillations or Synchrony? Disruption of Neural Synchrony despite Enhanced Gamma Oscillations in a Model of Disrupted Perceptual Coherence
Oscillations or Synchrony? Disruption of Neural Synchrony despite Enhanced Gamma Oscillations in a Model of Disrupted Perceptual Coherence
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DOI：
10.1162/jocn_a_00863
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发表时间：
2015-12-01
影响因子：
3.2
通讯作者：
Castelo-Branco, Miguel
中科院分区：
文献类型：
--
作者：
Castelhano, Joao;Bernardino, Ines;Castelo-Branco, Miguel
人们假设神经同步是感知一致性的基础。中枢知觉连贯性丧失的假说被认为是自闭症谱系障碍和威廉姆斯综合征（一种与自闭症相关的神经发育障碍）认知异常的根源，也是中枢连贯性受损的明确模型。我们利用这种整体处理受损的模型来测试这样的假设：神经同步性的丧失在使用脑电图的视觉整合中发挥着独立的作用，并进行了一组需要局部元素连贯整合以产生 3D 面部感知的实验任务。大脑活动发生了深刻的重组。不同刺激条件下的神经同步性会降低，这与 25-45 Hz 幅度调制的增加有关。尽管振荡活动增加，但同步性却急剧丧失，这有力地证明了同步性是中心连贯性的基础。据我们所知，这是第一次在感知一致性受损的人类模型中报告振幅和同步性之间的分离，这表明相位一致性的丧失与整体感知的破坏更直接相关。
It has been hypothesized that neural synchrony underlies perceptual coherence. The hypothesis of loss of central perceptual coherence has been proposed to be at the origin of abnormal cognition in autism spectrum disorders and Williams syndrome, a neurodevelopmental disorder linked with autism, and a clearcut model for impaired central coherence. We took advantage of this model of impaired holistic processing to test the hypothesis that loss of neural synchrony plays a separable role in visual integration using EEG and a set of experimental tasks requiring coherent integration of local elements leading to 3-D face perception. A profound reorganization of brain activity was identified. Neural synchrony was reduced across stimulus conditions, and this was associated with increased amplitude modulation at 25-45 Hz. This combination of a dramatic loss of synchrony despite increased oscillatory activity is strong evidence that synchrony underlies central coherence. This is the first time, to our knowledge, that dissociation between amplitude and synchrony is reported in a human model of impaired perceptual coherence, suggesting that loss of phase coherence is more directly related to disruption of holistic perception.