A meta-analysis of osteosarcoma outcomes in the modern medical era.
A meta-analysis of osteosarcoma outcomes in the modern medical era.
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作者：
Allison DC;Carney SC;Ahlmann ER;Hendifar A;Chawla S;Fedenko A;Angeles C;Menendez LR
四十年前，专门的化疗方案将骨肉瘤，一度被认为是一种致命的疾病，变成了一种大多数患者存活的疾病。虽然从20世纪60年代到80年代取得了显着的生存率提高，但进一步的结局改善似乎已经趋于稳定。本研究旨在全面回顾现代医学时代关于骨肉瘤及其结局的所有重要已发表数据，以评估治疗进展。我们的研究结果表明，从20世纪60年代到80年代，已发表的生存率显著提高，然后趋于平稳，或者在某些方面有所下降。复发率在20世纪70年代下降，然后持平。相比之下，公布的保肢率在最近十年中显著增加，直到现在。虽然在过去已经取得了显着的进步，但自1980年以来，已发表的骨肉瘤生存率没有改善，这突出了系统管理这种仍然非常致命的疾病的新策略的重要性。
Four decades ago, specialized chemotherapy regimens turned osteosarcoma, once considered a uniformly fatal disease, into a disease in which a majority of patients survive. Though significant survival gains were made from the 1960s to the 1980s, further outcome improvements appear to have plateaued. This study aims to comprehensively review all significant, published data regarding osteosarcoma and outcome in the modern medical era in order to gauge treatment progress. Our results indicate that published survival improved dramatically from 1960s to 1980s and then leveled, or in some measures decreased. Recurrence rates decreased in the 1970s and then leveled. In contrast, published limb salvage rates have increased significantly every recent decade until the present. Though significant gains have been made in the past, no improvement in published osteosarcoma survival has been seen since 1980, highlighting the importance of a new strategy in the systemic management of this still very lethal condition.