A case-control study of dietary and erythrocyte membrane fatty acids in asthma
A case-control study of dietary and erythrocyte membrane fatty acids in asthma
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DOI：
10.1111/j.1365-2222.2004.02032.x
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发表时间：
2004-08-01
影响因子：
6.1
通讯作者：
Fogarty, A
中科院分区：
文献类型：
--
作者：
Broadfield, EC;McKeever, TM;Fogarty, A
背景流行病学证据表明，增加膳食中ω-6脂肪酸的摄入和减少ω-3脂肪酸的摄入可能导致哮喘患病率的上升，但这些假设尚未在比较膳食摄入和多不饱和脂肪酸客观指标的研究中得到验证。目的评估是否摄入较高的ω-6脂肪酸或较低的ω-3脂肪酸摄入增加哮喘的风险，通过食物频率问卷（FFQ）和红细胞膜脂肪酸测量膳食脂肪酸摄入，方法我们比较了89例哮喘患者和89例社区匹配对照者的FFQ和空腹红细胞膜质谱法估计的个体脂肪酸摄入量。3种脂肪酸：二十碳五烯酸（摄入量第25和第75百分位数之间差异的比值比（OR）=1.89，95% CI 1.15-3.11）和二十二碳六烯酸（OR=2.11，95% CI 1.19-3.74）。没有证据表明红细胞膜中ω-3脂肪酸水平有任何差异，而哮喘的几率与亚油酸（ω-6）膜水平有关结论膳食中ω-3脂肪酸对哮喘的预防作用不明显，红细胞膜亚油酸水平越高，患哮喘的风险越低。
Background Epidemiological evidence suggests that increased dietary omega-6 and reduced omega-3 fatty acid intake, may have contributed to the rising prevalence of asthma, but these hypotheses have not been tested in studies comparing both dietary intake and objective measures of polyunsaturated fatty acids.Objective To assess whether a higher intake of omega-6 or a lower intake of omega-3 fatty acids increases the risk of asthma, by measuring dietary fatty acid intake by a food frequency questionnaire (FFQ) and erythrocyte membrane fatty acids, as an objective biomarker of intake.Methods We have compared individual fatty acid intake estimated by FFQ and by mass spectrometry of fasting erythrocyte cell membranes in 89 cases of asthma and 89 community-matched controls.Results The odds of asthma were increased in relation to intake of the omega-3 fatty acids eicosapentaenoic acid (odds ratio (OR) for difference between the 25th and 75th centiles of intake=1.89, 95% CI 1.15-3.11) and docosahexaenoic acid (OR=2.11, 95% CI 1.19-3.74). There was no evidence of any difference in erythrocyte membrane levels of omega-3 fatty acids, while the odds of asthma were reduced in relation to linoleic acid (omega-6) membrane levels (OR=0.45, 95% CI 0.21-0.95).Conclusion These findings suggest that dietary omega-3 fatty acids do not play a major role in protecting against asthma, and that higher levels of erythrocyte membrane linoleic acid are associated with a lower risk of asthma.