Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer's Disease and Normal Brain
Correlation of Early-Phase F-18 Florapronal PET with F-18 FDG PET in Alzheimer's Disease and Normal Brain
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DOI：
10.1007/s13139-019-00612-y
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发表时间：
2019-10-01
影响因子：
1.3
通讯作者：
Kang, Do-Young
中科院分区：
文献类型：
--
作者：
Jeong, Jieun;Jeong, Young Jin;Kang, Do-Young
F-18 florapronol（FPN）是韩国商业上认可的β-淀粉样蛋白正电子发射断层扫描（PET）放射性示踪剂。本研究比较了健康对照组（HC）和阿尔茨海默病（AD）患者的早期F-18氟代去氧葡萄糖（FDG）PET和F-18氟代去氧葡萄糖（FPN）PET。F-18 FDG PET图像采集时间为30 - 60 min，F-18 FPN PET采集时间为0 - 10 min。F-18 FPN和F-18 FDG图像采用从个体CT图像获得的变换矩阵和小脑区域的标准化摄取值比（SUVR）进行空间归一化，并使用PMOD 3.6计算全局平均值。结果比较了F-18 FDG和F-18 FPN在整体平均标准化和小脑标准化时对特定区域SUVR的影响，且大多数相关系数在整体平均标准化时较高。在整体平均标准化，相关系数HC的SUVR高于AD在所有的脑regions.Conclusions早期F-18 FPN研究可以作为一个代理标记的F-18 FDG PET。
Purpose F-18 florapronol (FPN) is the commercially recognized beta-amyloid positron emission tomography (PET) radiotracer in Korea. This study compared the early F-18 florapronol PET with F-18 fluorodeoxyglucose (FDG) PET between healthy controls (HC) and Alzheimer's dementia (AD) patients.Methods A total of 29 subjects (15 HC and 14 AD subjects) underwent F-18 FPN PET and F-18 FDG PET. F-18 FDG PET image was acquired from 30 to 60 min and F-18 FPN PET for 0 to 10 min. F-18 FPN and F-18 FDG images were spatially normalized with transformation matrices obtained from individual CT images and standardized uptake value ration (SUVR) from cerebellum area, and the global mean was calculated using PMOD 3.6. Pearson's correlation coefficients between F-18 FDG and early F-18 FPN for predefined cortical brain regions were calculated.Results We compared the F-18 FDG and F-18 FPN for SUVR of a specific region in global mean normalization and cerebellum normalization, and most of the correlation coefficient was higher in global mean normalization. In global mean normalization, the correlation coefficient for SUVR of HC was higher than that of AD in all brain regions.Conclusions Early F-18 FPN study can be used as a proxy marker for the F-18 FDG PET.