Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens.
Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens.
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DOI：
10.1016/j.vaccine.2012.01.070
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发表时间：
2012-03-16
期刊：
影响因子：
5.5
通讯作者：
Huang, Leaf
中科院分区：
文献类型：
--
作者：
Watson, Douglas S.;Endsley, Aaron N.;Huang, Leaf
脂质体（磷脂双层囊泡）是用于诱导抗体和T淋巴细胞对相关亚单位抗原应答的通用且稳健的递送系统。在过去的15年里，脂质体疫苗技术已经成熟，现在几种含有基于脂质体的佐剂的疫苗已经被批准用于人类使用或已经达到临床评估的后期阶段。鉴于人们对脂质体疫苗的兴趣日益浓厚，准确了解脂质体如何与免疫系统相互作用并刺激免疫力非常重要。已经清楚的是，脂质体疫苗的物理化学性质-抗原附着方法、脂质组成、双层流动性、颗粒电荷和其他性质-对所得免疫应答产生显著影响。在这里，我们提出了一个全面的审查脂质体疫苗的理化性质，以及它们如何影响免疫反应。还介绍了适合纳入脂质体疫苗的新型和新兴免疫调节剂的讨论。通过对脂质体疫苗文献的全面分析，我们列举了一系列原则，这些原则可以指导脂质体疫苗的合理设计，以引起所需幅度和质量的免疫应答。我们还确定了该领域尚未回答的主要问题，为今后的研究指明了方向。
Liposomes (phospholipid bilayer vesicles) are versatile and robust delivery systems for induction of antibody and T lymphocyte responses to associated subunit antigens. In the last 15 years, liposome vaccine technology has matured and now several vaccines containing liposome-based adjuvants have been approved for human use or have reached late stages of clinical evaluation. Given the intensifying interest in liposome-based vaccines, it is important to understand precisely how liposomes interact with the immune system and stimulate immunity. It has become clear that the physicochemical properties of liposomal vaccines – method of antigen attachment, lipid composition, bilayer fluidity, particle charge, and other properties – exert dramatic effects on the resulting immune response. Here, we present a comprehensive review of the physicochemical properties of liposomal vaccines and how they influence immune responses. A discussion of novel and emerging immunomodulators that are suitable for inclusion in liposomal vaccines is also presented. Through a comprehensive analysis of the body of liposomal vaccine literature, we enumerate a series of principles that can guide the rational design of liposomal vaccines to elicit immune responses of a desired magnitude and quality. We also identify major unanswered questions in the field, pointing the direction for future study.
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