SPINAL-CORD CONTUSION IN THE RAT - BEHAVIORAL-ANALYSIS OF FUNCTIONAL NEUROLOGIC IMPAIRMENT
SPINAL-CORD CONTUSION IN THE RAT - BEHAVIORAL-ANALYSIS OF FUNCTIONAL NEUROLOGIC IMPAIRMENT
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DOI：
10.1016/0014-4886(85)90118-9
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发表时间：
1985-01-01
影响因子：
5.3
通讯作者：
WRATHALL, JR
中科院分区：
文献类型：
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作者：
GALE, K;KERASIDIS, H;WRATHALL, JR
通过从2.5、5.0、10.0或17.5 cm处将10 g重物下落到T8椎骨水平的暴露硬脑膜上，在大鼠中产生分级的脊髓损伤。对这些体重下降（WD）水平中的每一个的大鼠组（N = 10）以及未手术和WD对照组（0cm）进行行为分析，包括简单和复杂反射以及自发和诱发运动模式的评价。在此分析的基础上，开发了一种用于评估大鼠脊髓损伤后功能缺陷的方案。由此产生的综合行为评分，一种功能缺陷的衡量标准，与机械损伤的程度密切相关。用于神经系统评估的方案由经过简单快速培训的人员进行常规管理。因此，它应该证明在检测治疗对脊髓损伤大鼠模型的功能恢复的影响是有用的。
A graded spinal cord injury in rats was produced by dropping a 10 g weight from 2.5, 5.0, 10.0 or 17.5 cm onto the exposed dura at the T8 vertebral level. Groups of rats (N = 10) for each of these weight drop (WD) levels as well as unoperated and WD controls (0 cm) were subjected to behavioral analysis that included evaluation of simple and complex reflexes as well as spontaneous and evoked motor patterns. On the basis of this analysis, a protocol was developed for evaluating functional deficits that follow spinal cord injury in the rat. The resulting combined behavioral score, a measure of functional deficit, closely correlated with the magnitude of the mechanical injury. The protocol used for neurologic assessment was administered routinely by personnel who were easily and rapidly trained. It should therefore prove useful in detecting the effects of treatment on recovery of function in a rat model of spinal cord injury.