Adiponectin is not altered with exercise training despite enhanced insulin action
Adiponectin is not altered with exercise training despite enhanced insulin action
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DOI：
10.1152/ajpendo.00150.2002
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发表时间：
2002-10-01
影响因子：
5.1
通讯作者：
Dohm, GL
中科院分区：
文献类型：
--
作者：
Hulver, MW;Zheng, DH;Dohm, GL
脂联素是一种脂肪细胞因子，推测其参与胰岛素作用的调节。本研究的目的是确定血浆脂联素是否随着运动训练的胰岛素作用增强而改变。在 6 个月的运动训练（每周 4 天，大约 45 分钟，65-80% 峰值 O-2 消耗）前后评估胰岛素敏感性指数 (SI) 以及葡萄糖、胰岛素和脂联素的空腹水平，且体重（PRE，91.9 +/- 3.8 kg 与 POST，91.6 +/- 3.9 kg）或脂肪量（PRE，26.5 +/- 1.8）没有损失。 kg 与 POST 比较，26.7 +/- 2.2 kg）。运动训练后胰岛素作用显着改善 (P < 0.05) (SI +98%)；然而，血浆脂联素浓度没有变化（PRE，6.3 +/- 1.5 μg/ml vs. POST，6.6 +/- 1.8 μg/ml）。相比之下，在减肥前后检查的另一组受试者中，脂联素大幅增加（+281%），同时胰岛素作用增强（S-I，+432%）。这些数据表明脂联素并不是运动相关的胰岛素敏感性改善的促成因素。
Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (SI) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for similar to45 min at 65-80% peak O-2 consumption) with no loss of body mass (PRE, 91.9 +/- 3.8 kg vs. POST, 91.6 +/- 3.9 kg) or fat mass (PRE, 26.5 +/- 1.8 kg vs. POST, 26.7 +/- 2.2 kg). Insulin action significantly (P < 0.05) improved with exercise training (SI +98%); however, plasma adiponectin concentration did not change (PRE, 6.3 +/- 1.5 mu g/ml vs. POST, 6.6 +/- 1.8 mu g/ml). In contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adiponectin (+281%), which was accompanied by enhanced insulin action (S-I, +432%). These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity.