Low-dose recombinant IL-2 induces psychological changes: monitoring by Minnesota Multiphasic Personality Inventory (MMPI).
Low-dose recombinant IL-2 induces psychological changes: monitoring by Minnesota Multiphasic Personality Inventory (MMPI).
复制标题
低剂量重组 IL-2 会引起心理变化：通过明尼苏达多相人格量表 (MMPI) 进行监测。
作者：
C. Pizzi;M. Caraglia;M. Cianciulli;A. Fabbrocini;A. Libroia;E. Matano;A. Contegiacomo;S. D. Del Prete;A. Abbruzzese;A. Martignetti;P. Tagliaferri;A. Bianco
背景
低剂量的慢性皮下注射 rIL-2 可产生持久的免疫调节作用，被认为是治疗肾细胞癌的有效方法，对恶性黑色素瘤和结直肠癌具有边缘活性。
患者和方法
在这项研究中，我们通过明尼苏达多相人格量表 (MMPI) 评估了 rIL-2 在 10 名晚期肿瘤患者中引起的心理变化。
结果
rIL-2治疗3个月后，80%的患者在抑郁症（D）和精神衰弱（Pt）临床量表上得分显着增加（p<0.01），70%在转换性癔症（Hy）量表上得分显着增加，60%在精神分裂症（Sc）和精神变态偏差（Pd）量表上得分显着增加（p<0.05）。然而，这些 MMPI 变化与疾病进展或临床明显的心理疾病并不平行。
结论
这些发现表明，低剂量rIL-2是一种精神活性治疗，值得进行心理监测。MMPI可用于评估细胞因子免疫治疗引起的亚临床心理改变。
BACKGROUND
Chronic subcutaneous rIL-2 at low doses produces long-lasting immunomodulatory effects and is considered an effective treatment for renal cell carcinoma with marginal activity in malignant melanoma and colorectal cancer.
PATIENTS AND METHODS
In this study we evaluated, by Minnesota Multiphasic Personality Inventory (MMPI), the psychological changes induced by rIL-2 in 10 patients with advanced tumors.
RESULTS
After 3 months of rIL-2 treatment, 80% of the patients had a significantly increased score on the clinical scale of depression (D) and psychasthenia (Pt) (p<0.01), 70% on the scale of conversion hysteria (Hy) and 60% on the scales of schizophrenia (Sc) and psychopathic deviate (Pd), (p<0.05). These MMPI changes were however not paralleled by disease progression or clinical-overt psychological disease.
CONCLUSION
These findings demonstrate that low-dose rIL-2 is a psychoactive treatment, which deserves psychological monitoring The MMPI is feasible for the evaluation of subclinical psychological modifications induced by cytokine immunotherapy.