Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study
Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study
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DOI：
10.1016/j.neuroimage.2011.05.037
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发表时间：
2011-08-15
期刊：
影响因子：
5.7
通讯作者：
Hajcak, Greg
中科院分区：
文献类型：
--
作者：
Carlson, Joshua M.;Foti, Dan;Hajcak, Greg
功能性磁共振成像（fMRI）研究表明，腹侧纹状体(VS)/伏隔核、内侧前额叶皮层（mPFC）和更广泛的中脑皮质边缘多巴胺系统介导了从奖励预期到获得奖励后的愉悦体验的奖励加工过程。与此同时，利用事件相关电位（ERP）的研究表明，反馈负性（FN）对奖励与非奖励反馈和结果期望敏感。FN的来源已经定位于mPFC和背纹状体，越来越多的证据表明FN反映了中皮质边缘系统的奖励处理。然而，在同一个体中，ERP和fMRI测量奖励处理的相关程度还有待探索。当前研究的主要目的是检查42名参与者在执行相同的金钱赌博任务时完成fMRI和ERP平衡会话的奖励处理测量之间的收敛性（即VS和mPFC）和ERP（即FN）。在Win>Loss对比中，包括VS和mPFC在内的中脑皮质边缘奖励回路的fMRI激活与FN正相关。在这里，我们证明了货币收益激活VS、mPFC、尾状核、杏仁核和眶额叶皮层，在反馈后300 ms内增强FN ERP成分，并且这些措施是相关的。因此，fMRI和ERP测量提供了奖励处理过程中中皮质边缘活动的补充信息，这可能有助于评估病理性奖励敏感性。(C) 2011爱思唯尔公司版权所有。
Functional magnetic resonance imaging (fMRI) research suggests that the ventral striatum (VS)/nucleus accumbens, medial prefrontal cortex (mPFC), and broader mesocorticolimbic dopamine system mediate aspects of reward processing from expectation of reward to pleasantness experienced upon reward attainment. In parallel, research utilizing event-related potentials (ERP) indicates that the feedback negativity (FN) is sensitive to reward vs. non-reward feedback and outcome expectation. The FN has been source localized to the mPFC and dorsal striatum, and converging evidence suggests that the FN reflects reward processing in the mesocorticolimbic system. However, the extent to which ERP and fMRI measures of reward processing are correlated has yet to be explored within the same individuals. The primary aim of the current study was to examine the convergence between fMRI (i.e., VS and mPFC) and ERP (i.e., FN) measures of reward processing in forty-two participants who completed counterbalanced fMRI and ERP sessions while performing the same monetary gambling task. For the Win>Loss comparison, fMRI activation in the mesocorticolimbic reward circuit including the VS and mPFC was positively correlated with the FN. Here, we demonstrate that monetary gains activate the VS, mPFC, caudate, amygdala, and orbital frontal cortex, enhance the FN ERP component within 300 ms post feedback, and that these measures are related. Thus, fMRI and ERP measures provide complementary information about mesocorticolimbic activity during reward processing, which may be useful in assessing pathological reward sensitivity. (C) 2011 Elsevier Inc. All rights reserved.